Center of Comparative Medicine (DC) and Diagnostic Pathology Laboratory (BS), Baylor College of Medicine, Houston, TX, 77030, USA.
BMC Vet Res. 2020 Nov 25;16(1):459. doi: 10.1186/s12917-020-02662-3.
Polyglactin 910 is a synthetic braided, absorbable suture commonly used in surgery. Though polyglactin 910 suture-related pseudoinfection is well documented in the human literature, it has not been previously reported in the veterinary literature.
A 3-year-old female, ovariectomized but otherwise experimentally naïve Yucatan pig was evaluated for a several week history of bilateral multifocal abscesses in the area of the paralumbar fossa, which continued to worsen despite oral antibiotics and non-steroidal anti-inflammatory medications. The multi-focal abscesses continued to worsen and additional diagnostics were pursued including cytology, culture (aerobic, anaerobic and fungal), and bloodwork. All supported a non-infectious etiology. Biopsy results indicated a suture-related pseudoinfection. Despite treatment including parenteral antibiotics, pain medications and superficial surgical debridement, the dermatologic lesions worsened. Euthanasia was elected. Post-mortem necropsy demonstrated a suture-related pseudoinfection with extrusion of suture material from the ovarian pedicle ligatures through the body wall and skin leading to numerous sterile abscesses in the bilateral paralumbar fossa.
This is the first published report of a significantly delayed polyglactin 910 suture-related pseudoinfection in a Yucatan pig. While likely an isolated incident, it supports further research into this area. Additionally for critical research studies using Yucatan pigs, pre-surgical assessment with hypersensitivity patch testing may be appropriate.
聚乳酸 910 是一种合成编织、可吸收缝线，常用于外科手术。尽管聚乳酸 910 缝线相关假性感染在人类文献中有充分记载，但在兽医文献中尚未报道过。
一只 3 岁雌性、卵巢切除但无其他手术史的尤卡坦猪，因双侧腰旁窝区域多发性局灶性脓肿病史数周就诊，尽管使用了口服抗生素和非甾体抗炎药，脓肿仍持续恶化。多发性脓肿持续恶化，进行了更多的诊断性检查，包括细胞学检查、培养（需氧、厌氧和真菌）和血液检查。所有检查均支持非传染性病因。活检结果提示为缝线相关假性感染。尽管进行了包括静脉内抗生素、止痛药和浅表性外科清创术在内的治疗，但皮肤病变仍恶化。因此选择了安乐死。尸检显示为缝线相关假性感染，缝线材料从卵巢蒂结扎处通过体壁和皮肤挤出，导致双侧腰旁窝内出现大量无菌脓肿。
这是首例报道的尤卡坦猪明显延迟的聚乳酸 910 缝线相关假性感染。虽然这可能是孤立事件，但支持进一步研究这一领域。此外，对于使用尤卡坦猪的关键研究，术前进行过敏斑贴试验可能是合适的。
