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[外源性脱氧核糖核酸酶对微生物DNA复制各阶段的影响]

[Effect of exogenous DNAses on various stages of DNA replication in microorganisms].

作者信息

Kupriianova F G, Kolpakov A I, Egorov S Iu

出版信息

Mol Gen Mikrobiol Virusol. 1987 Sep(9):30-5.

PMID:3323900
Abstract

Effect of DNAase 1 on DNA synthesis and cell division was studied in microorganisms deficient in some stages of DNA replication initiation. The DNA synthesis induced by exogenous DNAase was found to be a replicative origin since it was registered from the "origin" of chromosomal replication under the conditions of initiation of proteins functioning. Stimulation of DNA synthesis in bacterial cells having mutations in DNA B and DNA G genes by DNAase 1 indicates that exogenous DNAases participate in replicative fork during the DNA synthesis.

摘要

在DNA复制起始某些阶段存在缺陷的微生物中,研究了脱氧核糖核酸酶1(DNAase 1)对DNA合成和细胞分裂的影响。发现外源性DNAase诱导的DNA合成是一个复制起点,因为在蛋白质功能起始的条件下,它是从染色体复制的“起点”记录下来的。DNAase 1对DNA B和DNA G基因发生突变的细菌细胞中DNA合成的刺激表明,外源性DNAases在DNA合成过程中参与了复制叉的形成。

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