Jellinger K
Ludwig Boltzmann Institute of Clinical Neurobiology, Lainz Hospital University of Vienna, Austria.
Neurobiol Aging. 1987 Nov-Dec;8(6):556-61. doi: 10.1016/0197-4580(87)90134-5.
In normal aging, AD/SDAT and Parkinson's disease, the changes in subcortical neuronal systems are similar in quality and distribution, but highly variable in their intensity. Some correlations between the intensity and pattern of lesions in some subcortical nuclei with changes in cortical target areas in AD/SDAT suggest that age-related subcortical changes may represent a secondary phenomenon (antograde or retrograde degeneration) due to primary cortical damage. However, severe depletion of subcortical nuclei in both AD/SDAT and PD may also occur without considerable cortical pathology which is more compatible with a concomitant degeneration of both subcortical and intracortical neuronal systems.
在正常衰老、阿尔茨海默病/老年性痴呆（AD/SDAT）和帕金森病中，皮质下神经元系统的变化在性质和分布上相似，但强度变化很大。AD/SDAT中某些皮质下核团病变的强度和模式与皮质靶区变化之间的一些相关性表明，与年龄相关的皮质下变化可能是由于原发性皮质损伤导致的继发性现象（顺行性或逆行性变性）。然而，在AD/SDAT和帕金森病中，皮质下核团的严重耗竭也可能在没有明显皮质病理改变的情况下发生，这更符合皮质下和皮质内神经元系统同时发生变性的情况。
