HLA polymorphism and tapasin independence influence outcomes of HIV and dengue virus infection.
作者信息
Di Pucchio Tiziana, Sekaly Rafick-Pierre
机构信息
Pathology Advanced Translational Research Unit, Department of Pathology and Laboratory Medicine, Emory University School of Medicine, Atlanta, GA 30322.
Pathology Advanced Translational Research Unit, Department of Pathology and Laboratory Medicine, Emory University School of Medicine, Atlanta, GA 30322
出版信息
Proc Natl Acad Sci U S A. 2020 Dec 15;117(50):31570-31572. doi: 10.1073/pnas.2020109117. Epub 2020 Nov 25.
Abstract
摘要
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HLA polymorphism and tapasin independence influence outcomes of HIV and dengue virus infection.人类白细胞抗原多态性和TAP结合蛋白独立性影响HIV和登革病毒感染的结果。
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The quantity of naturally processed peptides stably bound by HLA-A*0201 is significantly reduced in the absence of tapasin.在缺乏塔帕辛的情况下，与HLA - A*0201稳定结合的天然加工肽的数量显著减少。
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本文引用的文献
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HLA tapasin independence: broader peptide repertoire and HIV control.HLA 肽结合蛋白独立性：更广泛的肽库与 HIV 控制。
Proc Natl Acad Sci U S A. 2020 Nov 10;117(45):28232-28238. doi: 10.1073/pnas.2013554117. Epub 2020 Oct 23.
2
Advances in the Evolutionary Understanding of MHC Polymorphism.MHC 多态性进化理解的进展。
Trends Genet. 2020 Apr;36(4):298-311. doi: 10.1016/j.tig.2020.01.008. Epub 2020 Feb 7.
3
Structural aspects of chaperone-mediated peptide loading in the MHC-I antigen presentation pathway.伴侣分子介导的 MHC-I 抗原呈递途径中肽加载的结构方面。
Crit Rev Biochem Mol Biol. 2019 Apr;54(2):164-173. doi: 10.1080/10409238.2019.1610352. Epub 2019 May 14.
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Molluscum contagiosum virus MC80 sabotages MHC-I antigen presentation by targeting tapasin for ER-associated degradation.传染性软疣病毒 MC80 通过靶向 tapasin 进行 ER 相关降解来破坏 MHC-I 抗原呈递。
PLoS Pathog. 2019 Apr 29;15(4):e1007711. doi: 10.1371/journal.ppat.1007711. eCollection 2019 Apr.
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Current Concepts of Antigen Cross-Presentation.抗原交叉呈递的当前概念
Front Immunol. 2018 Jul 16;9:1643. doi: 10.3389/fimmu.2018.01643. eCollection 2018.
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Loss of tapasin in human lung and colon cancer cells and escape from tumor-associated antigen-specific CTL recognition.人肺癌和结肠癌细胞中塔帕辛的缺失以及肿瘤相关抗原特异性CTL识别逃逸。
Oncoimmunology. 2017 Jan 3;6(2):e1274476. doi: 10.1080/2162402X.2016.1274476. eCollection 2017.
7
Major histocompatibility complex genomics and human disease.主要组织相容性复合体基因组学与人类疾病。
Annu Rev Genomics Hum Genet. 2013;14:301-23. doi: 10.1146/annurev-genom-091212-153455. Epub 2013 Jul 15.
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HLA-F and MHC-I open conformers cooperate in a MHC-I antigen cross-presentation pathway.HLA-F 和 MHC-I 开放构象在 MHC-I 抗原交叉呈递途径中合作。
J Immunol. 2013 Aug 15;191(4):1567-77. doi: 10.4049/jimmunol.1300080. Epub 2013 Jul 12.
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The MHC I loading complex: a multitasking machinery in adaptive immunity.MHC I 加载复合物：适应性免疫中的多功能机器。
Trends Biochem Sci. 2013 Aug;38(8):412-20. doi: 10.1016/j.tibs.2013.06.003. Epub 2013 Jul 10.
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Antigen processing and presentation: evolution from a bird's eye view.抗原加工和呈递：从鸟瞰视角看进化。
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