The Epidemiology, Economics and Risk Assessment (EERA) Group, The Roslin Institute and The Royal (Dick) School of Veterinary Studies, Easter Bush Veterinary Centre, The University of Edinburgh, Roslin, EH25 9RG, Midlothian, UK.
Centre for Tropical Livestock Genetics and Health (CTLGH), The Roslin Institute, University of Edinburgh, Easter Bush Campus, Roslin, EH25 9RG, UK.
Sci Rep. 2020 Nov 25;10(1):20590. doi: 10.1038/s41598-020-77209-5.
Vitamin D plays a critical role in calcium homeostasis and in the maintenance and development of skeletal health. Vitamin D status has increasingly been linked to non-skeletal health outcomes such as all-cause mortality, infectious diseases and reproductive outcomes in both humans and veterinary species. We have previously demonstrated a relationship between vitamin D status, assessed by the measurement of serum concentrations of the major vitamin D metabolite 25 hydroxyvitamin D (25(OH)D), and a wide range of non-skeletal health outcomes in companion and wild animals. The aims of this study were to define the host and environmental factors associated with vitamin D status in a cohort of 527 calves from Western Kenya which were part of the Infectious Disease of East African Livestock (IDEAL) cohort. A secondary aim was to explore the relationship between serum 25(OH)D concentrations measured in 7-day old calves and subsequent health outcomes over the following 12 months. A genome wide association study demonstrated that both dietary and endogenously produced vitamin D metabolites were under polygenic control in African calves. In addition, we found that neonatal vitamin D status was not predictive of the subsequent development of an infectious disease event or mortality over the 12 month follow up period.
维生素 D 在钙稳态和骨骼健康的维持和发育中起着关键作用。维生素 D 状况与非骨骼健康结果（如全因死亡率、传染病和人类及兽医物种的生殖结果）的关系日益密切。我们之前已经证明了维生素 D 状态（通过测量主要维生素 D 代谢物 25 羟维生素 D（25(OH)D）的血清浓度来评估）与伴侣动物和野生动物的广泛非骨骼健康结果之间存在关系。本研究的目的是确定 527 头来自肯尼亚西部的小牛的宿主和环境因素与维生素 D 状态之间的关系，这些小牛是东非牲畜传染病（IDEAL）队列的一部分。次要目的是探索在 7 天大的小牛中测量的血清 25(OH)D 浓度与随后 12 个月内的健康结果之间的关系。全基因组关联研究表明，非洲小牛的饮食和内源性产生的维生素 D 代谢物均受多基因控制。此外，我们发现新生儿维生素 D 状态并不能预测随后 12 个月随访期间传染病事件或死亡率的发生。
