Department of Pediatrics, Kalinga Institute of Medical Sciences, Bhubaneswar, Odisha, India.
Department of Neonatology, IMS & SUM Hospital, Bhubaneswar, Odisha, India.
Indian J Pediatr. 2020 Jun;87(6):427-432. doi: 10.1007/s12098-020-03188-0. Epub 2020 Feb 13.
To evaluate the effect of maternal/ neonatal vitamin D levels on culture positive neonatal sepsis.
This prospective cohort study was conducted in the NICU of a tertiary care teaching hospital in Odisha, Eastern India from January 2015 through December 2016. Forty (40) neonates with culture positive sepsis were included in the study group. Forty (40) healthy neonates admitted for evaluation of neonatal jaundice who are similar in gender, gestational age, postnatal age and without any clinical signs of sepsis were recruited as control group after informed consent. Vitamin D level (25 OH D) was assessed in the neonates and their mothers in both the groups.
Neonatal 25 OH vitamin D level in the study group (12.71 ± 2.82 ng/ml) was significantly lower than in the control group (25.46 ± 7.02 ng/ml). The Odds ratio was 273 (95% CI 30.39-2451.6) for culture positive sepsis in neonates with vitamin D deficiency/insufficiency. Mothers of septic neonates had significantly lower 25 OH vitamin D level (20.92 ± 3.92 ng/ml) than the mothers of healthy neonates in control group (27.31 ± 6.83 ng/ml). The Odds ratio was 4.71 (95% CI 1.69-13.1) for culture positive sepsis in babies born to mothers with vitamin D deficiency/insufficiency.
Neonates with vitamin D deficiency/insufficiency are at higher risk for developing sepsis than those with sufficient vitamin D levels. Lower vitamin D levels in mothers is also associated with increased risk of sepsis in the neonates.
评估母/新生儿维生素 D 水平对培养阳性新生儿败血症的影响。
本前瞻性队列研究于 2015 年 1 月至 2016 年 12 月在印度东部奥里萨邦的一家三级护理教学医院的 NICU 进行。研究组纳入 40 例培养阳性败血症的新生儿。40 例因新生儿黄疸评估而入院的健康新生儿被招募为对照组，这些新生儿在性别、胎龄、生后年龄方面相似，且无任何败血症临床征象，并在知情同意后纳入。评估两组新生儿及其母亲的维生素 D 水平（25-羟维生素 D）。
研究组新生儿 25-羟维生素 D 水平（12.71±2.82ng/ml）明显低于对照组（25.46±7.02ng/ml）。维生素 D 缺乏/不足的新生儿发生培养阳性败血症的比值比为 273（95%CI 30.39-2451.6）。败血症新生儿的母亲 25-羟维生素 D 水平（20.92±3.92ng/ml）明显低于对照组健康新生儿的母亲（27.31±6.83ng/ml）。维生素 D 缺乏/不足的母亲所生婴儿发生培养阳性败血症的比值比为 4.71（95%CI 1.69-13.1）。
与维生素 D 水平充足的新生儿相比，维生素 D 缺乏/不足的新生儿发生败血症的风险更高。母亲的维生素 D 水平较低也与新生儿败血症的风险增加相关。
