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新型2型糖尿病治疗方法:胰高血糖素样肽受体(GLPR)激动剂和钠-葡萄糖协同转运蛋白2(SGLT2)抑制剂这两类药物的比较

The new type 2 diabetes mellitus therapy: comparison between the two classes of drugs GLPR (glucagon-like peptide receptor) agonists and SGLT2 (sodium-glucose cotransporter 2) inhibitors.

作者信息

Borghi Claudio, Bragagni Alessio

机构信息

Dipartimento di Scienze Mediche e Chirurgiche, Cattedra di Medicina Interna, Università degli Studi di Bologna.

出版信息

Eur Heart J Suppl. 2020 Nov 18;22(Suppl L):L28-L32. doi: 10.1093/eurheartj/suaa129. eCollection 2020 Nov.

Abstract

Type 2 diabetes mellitus represents one of the most common chronic-degenerative diseases in modern society and is the cause of innumerable micro- and macrovascular complications that weigh on the national health system. Until a few years ago, there was no anti-diabetic drug that, in addition to lowering blood sugar, had an impact on cardiovascular risk in these patients. In this report, we will analyse the characteristics, contraindications, and evidence in favour of the use of two innovative categories of molecules that aim, for the first time in history, at controlling blood sugar levels and simultaneously lower cardiovascular risk in diabetics individuals: the glucagon-like peptide receptor agonists and the sodium-glucose cotransporter 2 inhibitors.

摘要

2型糖尿病是现代社会最常见的慢性退行性疾病之一,也是导致无数微血管和大血管并发症的原因,给国家卫生系统带来了沉重负担。直到几年前,还没有一种抗糖尿病药物除了能降低血糖外,还能对这些患者的心血管风险产生影响。在本报告中,我们将分析两类创新分子的特性、禁忌症以及支持其使用的证据,这两类分子有史以来首次旨在控制血糖水平并同时降低糖尿病患者的心血管风险:胰高血糖素样肽受体激动剂和钠-葡萄糖协同转运蛋白2抑制剂。

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