Manoranjan Branavan, Adile Ashley A, Venugopal Chitra, Singh Sheila K
Section of Neurosurgery, Department of Clinical Neurosciences, University of Calgary, Calgary, Alberta, Canada.
Departments of Biochemistry and Biomedical Sciences, McMaster University, Hamilton, Ontario, Canada.
Mol Cell Oncol. 2020 Oct 25;7(6):1834903. doi: 10.1080/23723556.2020.1834903. eCollection 2020.
Medulloblastoma (MB) represents the most common malignant pediatric brain tumor and is defined by four molecular subgroups with WNT MB having the most favorable prognosis. Our work provides a rational therapeutic option in which the protective effects of WNT-driven MBs may be augmented in Group 3 and 4 MB.
髓母细胞瘤（MB）是最常见的儿童恶性脑肿瘤，由四个分子亚组定义，其中WNT亚组的髓母细胞瘤预后最为良好。我们的研究提供了一种合理的治疗选择，即在3型和4型髓母细胞瘤中增强WNT驱动的髓母细胞瘤的保护作用。
