Basir Eye Health Research Center, Tehran, Iran.
Department of Ophthalmology, Imam Hossein Hospital, Shahid Beheshti University of Medical Sciences, Tehran, Iran.
Eur J Ophthalmol. 2022 Jan;32(1):282-287. doi: 10.1177/1120672120972626. Epub 2020 Nov 26.
To investigate the long-term effect of serous choroidal detachment on the success of trabeculectomy in glaucoma patients.
In this case-control study, 17 patients who underwent trabeculectomy and developed choroidal detachment, and completed at least 3 years of follow-up were included. The controls were matched based on age, sex, preoperative intraocular pressure, and glaucoma type, and lack of choroidal detachment. Surgical success was defined based on two definitions of 5 < IOP < 16 and 20% reduction from the baseline and no need for further glaucoma surgery and all the same but 5 < IOP < 22.
The mean estimated duration of survival ±SD was 2.73 ± 0.35 years (CI 95% 2.1, 3.4), which was significantly shorter than 3.98 ± 0.38 years (CI 95% 3.3, 4.7) in the control group. (LogRank = 5.03 = 0.02). Cumulative probability of success was 76.5%, 52.9%, 29.4%, 17.6%, and 11.8% in year 1, 2, 3, 4, and 5 in the case group, respectively. Corresponding values were 88.2%, 82.4%, 68.6%, 58.8%, and 47.1%. In the control group, respectively. At baseline, average IOP was 22.3 ± 2.7 and 23.8 ± 8.3 mmHg in the case and control groups, respectively ( = 0.17). Mean IOP was significantly higher in the case group than in the control group in years 2, 3, 4, and 5.
Serous choroidal detachment affects the long-term surgical success of trabeculectomy, especially in patients with advanced glaucoma when lower target pressure is required.
研究在青光眼患者中,脉络膜脱离对小梁切除术成功的长期影响。
在这项病例对照研究中,纳入了 17 名接受小梁切除术并发生脉络膜脱离的患者,这些患者至少完成了 3 年的随访。对照组根据年龄、性别、术前眼压和青光眼类型以及无脉络膜脱离进行匹配。手术成功定义基于两种定义:5<眼压<16mmHg 和从基线水平下降 20%且无需进一步青光眼手术,以及所有相同但 5<眼压<22mmHg。
平均估计生存时间±SD 为 2.73±0.35 年(95%CI 95%为 2.1,3.4),明显短于对照组的 3.98±0.38 年(95%CI 95%为 3.3,4.7)。(对数秩检验 = 5.03, = 0.02)。病例组在第 1、2、3、4 和 5 年的累积成功率分别为 76.5%、52.9%、29.4%、17.6%和 11.8%,对照组分别为 88.2%、82.4%、68.6%、58.8%和 47.1%。在基线时,病例组和对照组的平均眼压分别为 22.3±2.7mmHg 和 23.8±8.3mmHg( = 0.17)。病例组在第 2、3、4 和 5 年的平均眼压明显高于对照组。
脉络膜脱离会影响小梁切除术的长期手术成功率,尤其是在需要较低目标眼压的晚期青光眼患者中。