Rapp M A, Tschorn M, Supprian T, Thomas C, Kreisel S, Benninghoff J, Schumann G, Heinz A
Sozial- und Präventivmedizin, Department Sport- und Gesundheitswissenschaften, Strukturbereich Kognitionswissenschaften, Universität Potsdam, Am Neuen Palais 10, 14469, Potsdam, Deutschland.
Abteilung Gerontopsychiatrie, LVR-Klinikum Düsseldorf, Kliniken der Heinrich-Heine-Universität, Düsseldorf, Deutschland.
Nervenarzt. 2021 Mar;92(3):219-227. doi: 10.1007/s00115-020-01035-3. Epub 2020 Nov 26.
The sizeable number of population-based cohort studies of aging in Germany have provided highly valuable contributions for the specification of risk factors and predictors for frequent mental disorders in old age, especially dementia and depression. The results from these cohort studies enable the specification of mechanisms for the development of and preventative interventions for common mental disorders in old age. On the other hand, there is a significant paucity of clinical cohort studies investigating disease trajectories and possible markers for specific individualized interventions of frequent mental disorders in old age. In this article, we report selected key findings from cohort studies of aging and discuss novel approaches for the integration and harmonization of population-based and clinical cohort studies.
德国开展了大量基于人群的衰老队列研究，这些研究为明确老年常见精神障碍（尤其是痴呆和抑郁症）的风险因素及预测指标做出了极具价值的贡献。这些队列研究的结果有助于明确老年常见精神障碍的发病机制及预防性干预措施。另一方面，针对老年常见精神障碍的疾病轨迹以及特定个体化干预的可能标志物进行研究的临床队列研究却极为匮乏。在本文中，我们报告了衰老队列研究的部分关键发现，并讨论了整合与协调基于人群的队列研究和临床队列研究的新方法。
