Department of Pathology and Cell Biology, Columbia University, 630W 168(th) Street, New York, NY 10032, USA; Taub Institute for Research on Alzheimer's Disease and the Aging Brain, Columbia University, 630W 168(th) Street, New York, NY 10032, USA; Department of Medicine, Columbia University, 630W 168(th) Street, New York, NY 10032, USA.
Neuron. 2020 Nov 25;108(4):583-585. doi: 10.1016/j.neuron.2020.11.003.
Amyloid-β precursor protein (APP) is overshadowed by its degradation product, the Alzheimer protein Aβ. Lee et al. now find a role for the APP family in neuronal excitability, synaptic plasticity, and memory in adulthood, despite the lack of requirement for neuronal survival.
淀粉样前体蛋白（APP）因其降解产物阿尔茨海默病相关蛋白 Aβ而黯然失色。然而，Lee 等人现在发现 APP 家族在成年期神经元兴奋性、突触可塑性和记忆中具有重要作用，尽管其对于神经元存活没有需求。
