Department of Food Processing, Bolvadin Vocational School, Afyon Kocatepe University, 03300, Afyonkarahisar, Turkey.
Int J Biol Macromol. 2021 Jan 31;168:823-833. doi: 10.1016/j.ijbiomac.2020.11.147. Epub 2020 Nov 24.
In this study, ionically crosslinked beads of sodium alginate (NaAlg) and methylcellulose (MC) were prepared as semi-interpenetrating polymer networks (semi-IPN) in the size range of 1.97 ± 0.09-1.22 ± 0.13 mm by crosslinking with FeCl and loaded with ibuprofen (IBU), which is a nonsteroidal anti-inflammatory drug. The highest 93.33% entrapment efficiency of IBU was achieved, and the drug release behaviors, mean particle size, and entrapment efficiency of beads were investigated in terms of the polymer composition, a ratio of ibuprofen to polymer, exposure time to crosslinker, and concentration of the crosslinking agent. Semi-IPN formulations prepared were also characterized using Fourier transform infrared (FTIR) spectroscopy, differential scanning calorimetry (DSC), X-ray Diffraction (X-RD), and scanning electron microscopy (SEM). It was observed that IBU-loaded beads displayed better release performance with an increase amount of NaAlg in the structure. Finally, the optimum IBU release was obtained as 93.9% for beads containing 66.7% (w/w) NaAlg, 33.3% (w/w) MC, IBU/polymer ratio of 1/4, FeCl concentration of 0.1 M, and crosslinking time of 90 min. The in vitro release rate was fitted to five empirical equations, and the diffusion exponent n, which indicated that the release mechanism of IBU from beads followed the Anomalous and Case II transport mechanism.
在这项研究中，通过用 FeCl 交联，制备了尺寸在 1.97±0.09-1.22±0.13mm 范围内的海藻酸钠（NaAlg）和甲基纤维素（MC）的离子交联珠，作为半互穿聚合物网络（semi-IPN），并负载布洛芬（IBU），这是一种非甾体抗炎药。IBU 的最高包封效率达到了 93.33%，并研究了珠子的药物释放行为、平均粒径和包封效率，这些参数与聚合物组成、IBU 与聚合物的比例、交联剂暴露时间和交联剂浓度有关。还使用傅里叶变换红外（FTIR）光谱、差示扫描量热法（DSC）、X 射线衍射（X-RD）和扫描电子显微镜（SEM）对制备的 semi-IPN 配方进行了表征。结果表明，随着结构中 NaAlg 含量的增加，IBU 负载珠显示出更好的释放性能。最后，对于含有 66.7%（w/w）NaAlg、33.3%（w/w）MC、IBU/聚合物比为 1/4、FeCl 浓度为 0.1 M 和交联时间为 90 min 的珠子，获得了最佳的 IBU 释放量为 93.9%。体外释放率拟合了五个经验方程，扩散指数 n 表明 IBU 从珠中的释放机制遵循异常和案例 II 传输机制。
