Gareri Pietro, Cotroneo Antonino Maria, Orsitto Giuseppe, Putignano Salvatore
Center for Cognitive Disorders and Dementia, Catanzaro Lido, ASP Catanzaro, Catanzaro, Italy.
Department of Elderly Health Care, Birago di Vische Hospital and Botticelli Territorial Geriatrics - ASL TO 2, Turin, Italy.
Rev Recent Clin Trials. 2021;16(2):126-130. doi: 10.2174/1574887115999201126205538.
Citicoline is a drug used both in degenerative and in vascular cognitive decline; memantine is a drug used for the treatment of mild to moderate Alzheimer's disease (AD). Our hypothesis is that their combined use could have enhanced action in patients having AD and mixed dementia (MD). We report the main tips from a recent study on the use of these drugs, the CITIMEM study.
The study was retrospective and was performed on 126 patients aged 65 years old or older affected with AD or MD (mean age 80.7 ± 5.2 years old) who had been visited between 2015 and 2017 in four different centers for dementia all over Italy. Neuropsychological and functional tests were administered at baseline (T0), after 6 (T1), and 12 months (T2). The effects of combined treatment versus memantine alone on cognitive functions assessed by Mini-Mental State Examination (MMSE) and the possible onset of side effects or adverse events, as well as the influence on daily life functions and behavioral symptoms, were investigated.
Patients undergoing combined treatment showed a significant increase in MMSE vs. memantine alone, both at T1 (p=0.003) and T2 (p =0.000).
The CITIMEM study confirms our hypothesis that the combined administration of memantine plus citicoline is safe and more effective than memantine alone on cognition in patients suffering from AD or MD.
胞磷胆碱是一种用于治疗退行性和血管性认知功能减退的药物；美金刚是一种用于治疗轻度至中度阿尔茨海默病（AD）的药物。我们的假设是，它们联合使用可能对患有AD和混合性痴呆（MD）的患者具有增强的疗效。我们报告了最近一项关于这些药物使用的研究（CITIMEM研究）的主要要点。
该研究为回顾性研究，对2015年至2017年期间在意大利四个不同的痴呆症中心就诊的126例65岁及以上患有AD或MD的患者（平均年龄80.7±5.2岁）进行。在基线（T0）、6个月（T1）和12个月（T2）后进行神经心理学和功能测试。研究了联合治疗与单独使用美金刚对通过简易精神状态检查表（MMSE）评估的认知功能的影响、副作用或不良事件的可能发生情况，以及对日常生活功能和行为症状的影响。
联合治疗的患者在T1（p=0.003）和T2（p =0.000）时，MMSE较单独使用美金刚有显著增加。
CITIMEM研究证实了我们的假设，即美金刚加胞磷胆碱联合给药对患有AD或MD的患者的认知是安全的，且比单独使用美金刚更有效。
