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大麻二酚增强人头颈鳞状细胞癌细胞毒药物的细胞毒性。

Cannabidiol enhances cytotoxicity of anti-cancer drugs in human head and neck squamous cell carcinoma.

机构信息

Department of Otorhinolaryngology-Head and Neck Surgery, Korea University Guro Hospital, 80 Guro-dong, Guro-gu, Seoul, 08308, South Korea.

Institute for Health Care Convergence Center, Korea University Guro Hospital, Seoul, Republic of Korea.

出版信息

Sci Rep. 2020 Nov 26;10(1):20622. doi: 10.1038/s41598-020-77674-y.

DOI:10.1038/s41598-020-77674-y
PMID:33244087
原文链接:https://pmc.ncbi.nlm.nih.gov/articles/PMC7692486/
Abstract

Cannabidiol (CBD) has anti-tumorigenic activity. However, the anti-cancer effect of CBD on head and neck squamous cell carcinoma (HNSCC) remains unclear. The cytotoxicity of CBD on HNSCC was analyzed using cell survival and colony-forming assays in vitro. RNA-seq was used for determining the mechanism underlying CBD-induced cell death. Xenograft mouse models were used to determine CBD's effects in vivo. CBD treatment significantly reduced migration/invasion and viability of HNSCC cells in a dose- and time-dependent manner. HNSCC mouse xenograft models revealed anti-tumor effects of CBD. Furthermore, combinational treatment with CBD enhanced the efficacy of chemotherapy drugs. Apoptosis and autophagy processes were involved in CBD-induced cytotoxicity of HNSCCs. RNA-seq identified decreased expression of genes associated with DNA repair, cell division, and cell proliferation, which were involved in CBD-mediated cytotoxicity toward HNSCCs. We identified CBD as a new potential anti-cancer compound for single or combination therapy of HNSCC.

摘要

大麻二酚 (CBD) 具有抗肿瘤活性。然而，CBD 对头颈部鳞状细胞癌 (HNSCC) 的抗癌作用尚不清楚。体外细胞存活和集落形成实验分析了 CBD 对 HNSCC 的细胞毒性。RNA-seq 用于确定 CBD 诱导细胞死亡的机制。异种移植小鼠模型用于体内确定 CBD 的作用。CBD 处理以剂量和时间依赖的方式显著降低了 HNSCC 细胞的迁移/侵袭和活力。HNSCC 小鼠异种移植模型显示了 CBD 的抗肿瘤作用。此外，CBD 联合化疗药物增强了化疗药物的疗效。凋亡和自噬过程参与了 CBD 诱导的 HNSCC 细胞毒性。RNA-seq 鉴定出与 DNA 修复、细胞分裂和细胞增殖相关的基因表达下调，这些基因参与了 CBD 介导的 HNSCC 细胞毒性。我们将 CBD 鉴定为一种新的潜在抗癌化合物，可用于 HNSCC 的单一或联合治疗。

https://cdn.ncbi.nlm.nih.gov/pmc/blobs/ef09/7692486/18c9338e5c33/41598_2020_77674_Fig7_HTML.jpg
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https://cdn.ncbi.nlm.nih.gov/pmc/blobs/ef09/7692486/18c9338e5c33/41598_2020_77674_Fig7_HTML.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/ef09/7692486/c1a9697aa755/41598_2020_77674_Fig1_HTML.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/ef09/7692486/e2a314d47f72/41598_2020_77674_Fig2_HTML.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/ef09/7692486/4419fedd757a/41598_2020_77674_Fig3_HTML.jpg
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