Gastrointestinal Cancer Research Group, Department of Surgery, University of KwaZulu-Natal, Durban, South Africa.
Faculty of Health and Environmental Sciences, Central University of Technology, Bloemfontein, South Africa.
Pan Afr Med J. 2020 Sep 18;37:74. doi: 10.11604/pamj.2020.37.74.21313. eCollection 2020.
the burden of colorectal carcinoma (CRC), once considered rare in Africa, may be changing with the disease being increasingly diagnosed and there is a suggestion that age and race influence tumour behaviour. We sought to describe the clinicopathological spectrum of CRC among the different race and age groups in a South African setting.
analysis of prospectively collected data from an on-going colorectal cancer database, including demographics, clinical presentation, site, staging and grading on all patients enrolled over an 18-year period.
a total of 2232 patients with CRC were accrued over the study period (Africans, 798; Indians, 890; Coloureds, 104; and Whites, 440). Mean age was 57.7 (SD 14.4) but varied considerably by race (p < 0.001) with Africans being significantly younger. Young adults (aged < 40 years) totalled 305 and older patients (aged > 40 years) totalled 1927. The proportion of young patients (< 40 years old) was 28%, 7%, 9% and 3% among Africans, Indian, Coloured and White patients respectively. There were minimal variations in anatomical sub-site distribution. There was no difference in tumour stage between the various races and between older and young adults. Mucinous differentiation was more common in Africans and in young patients and poor differentiation was more common in African patients. Africans had a significantly lower resection rate compared to the other race groups (p < 0.001). Younger patients had a significantly lower resection rate compared to the older age group (p < 0.001).
African patients were the youngest compared to the other race groups. Mucinous differentiation predominated in Africans and young adults. Poor differentiation predominated in Africans. Resection rate was lower for African patients and in young patients.
结直肠癌（CRC）的负担曾经被认为在非洲很少见，但随着该疾病的诊断日益增多，这种情况可能正在发生变化，并且有迹象表明年龄和种族会影响肿瘤的行为。我们试图描述南非不同种族和年龄组 CRC 的临床病理谱。
对一项正在进行的结直肠癌数据库中前瞻性收集的数据进行分析，包括所有入组患者的人口统计学、临床表现、部位、分期和分级，研究时间为 18 年。
在研究期间共收治了 2232 例 CRC 患者（非洲人 798 例，印度人 890 例，有色人种 104 例，白种人 440 例）。平均年龄为 57.7（SD 14.4），但因种族而异（p <0.001），非洲人明显更年轻。年轻人（<40 岁）总计 305 例，年龄较大的患者（>40 岁）总计 1927 例。<40 岁的年轻患者分别占非洲人、印度人、有色人种和白人患者的 28%、7%、9%和 3%。解剖亚部位分布差异极小。不同种族之间以及年龄较大和年轻患者之间的肿瘤分期没有差异。黏液分化在非洲人和年轻患者中更为常见，而分化不良在非洲患者中更为常见。非洲患者的切除率明显低于其他种族群体（p <0.001）。年轻患者的切除率明显低于年龄较大的年龄组（p <0.001）。
与其他种族群体相比，非洲患者是最年轻的。黏液分化在非洲人和年轻人中更为常见。分化不良在非洲患者中更为常见。非洲患者和年轻患者的切除率较低。
