School of Pharmacy, University of Nottingham, University Park, Nottingham, NG7 2RD, UK.
Division of Biomedical Sciences, School of Pharmacy, University of Nottingham Malaysia, 43500, Semenyih, Selangor, Malaysia.
Mol Biol Rep. 2020 Dec;47(12):9883-9894. doi: 10.1007/s11033-020-06025-x. Epub 2020 Nov 26.
This appraisal is comprised of the inflammatory studies that have been conducted on Clinacanthus nutans, Acanthus ebracteatus, and Barleria lupulina. The review aims to provide a comprehensive evaluation of the supporting and contradictory evidence on each plants' anti-inflammatory properties, whilst addressing the gaps in the current literature. The databases used to obtain relevant studies were Google Scholar, ResearchGate, PubMed and Nusearch (University of Nottingham). A total of 13 articles were selected for this review. A. ebracteatus was found to suppress neutrophil migration and weakly inhibits chronic inflammatory cytokines. Furthermore, B. lupulina and C. nutans were shown to possess very similar anti-inflammatory properties. The studies on C. nutans indicated that its anti-inflammatory effect is strongly related to the inhibition of toll-like receptor 4 (TLR4). Moreover, several phytoconstituents isolated from B. lupulina were shown to activate the anti-inflammatory Nrf2 pathway. Overall, all the studies have provided evidence to support the use of these plants as anti-inflammatory herbal remedies. However, their exact mechanism of action and the responsible phytoconstituents are yet to be established.
本评价涵盖了对 Clinacanthus nutans、Acanthus ebracteatus 和 Barleria lupulina 的炎症研究。本综述旨在全面评估这些植物抗炎特性的支持和矛盾证据，同时解决当前文献中的空白。用于获取相关研究的数据库是 Google Scholar、ResearchGate、PubMed 和 Nusearch（诺丁汉大学）。共有 13 篇文章被选入本综述。研究发现，A. ebracteatus 可抑制中性粒细胞迁移，并可弱抑制慢性炎症细胞因子。此外，B. lupulina 和 C. nutans 表现出非常相似的抗炎特性。对 C. nutans 的研究表明，其抗炎作用与抑制 toll 样受体 4（TLR4）密切相关。此外，从 B. lupulina 中分离出的几种植物成分被证明可以激活抗炎 Nrf2 通路。总的来说，所有的研究都提供了证据支持这些植物作为抗炎草药的使用。然而，它们的确切作用机制和负责的植物成分尚待确定。
