Department of Radiation Oncology, Faculty of Medicine, Hacettepe University, Ankara, Turkey.
Department of Preventive Oncology, Faculty of Medicine, Hacettepe University, Ankara, Turkey.
Head Neck. 2021 Apr;43(4):1122-1127. doi: 10.1002/hed.26556. Epub 2020 Nov 27.
Our aim was to evaluate the correlation between the radiation doses to parotid gland (PG) stem cells and xerostomia.
Patients diagnosed with head and neck cancer (HNC) were retrospectively evaluated, and xerostomia inventory (XI) was applied to these patients. PG stem cells were delineated on the treatment planning CT, and the mean doses to the PG stem cells calculated.
The total test score and mean doses to bilateral PGs were significantly correlated (r = .34, P = .001), and the mean doses to bilateral PG stem cell niches were significantly correlated with the total test score (r = .32, P = .002).
In this study, we found that the mean dose to PG stem cells can predict dry mouth as much as the mean dose to the PG.
我们旨在评估腮腺干细胞的辐射剂量与口干症之间的相关性。
回顾性评估诊断为头颈部癌症（HNC）的患者，并对这些患者应用口干症量表（XI）。在治疗计划 CT 上勾画腮腺干细胞，并计算腮腺干细胞的平均剂量。
总测试评分与双侧腮腺的平均剂量呈显著相关（r =.34，P =.001），双侧腮腺干细胞龛的平均剂量与总测试评分呈显著相关（r =.32，P =.002）。
在这项研究中，我们发现腮腺干细胞的平均剂量可以像腮腺的平均剂量一样预测口干症。
