Hofmann W, Rumohr T, Patsch R
Klinik und Poliklinik für Urologie, Bereiches Medizin der Martin-Luther-Universität, Halle-Wittenberg.
Z Urol Nephrol. 1987 Oct;80(10):595-600.
On the basis of a clinical study an analysis about 86 patients with obstructing bilateral nephrolithiasis and chronic obstructive infection of the urinary tract is elaborated. In order to illustrate the change of resistance of the causative agents during a period of 10 years (1973-1982) two separated 5-year analyses are compared. It is made evident that the relations of sensitivity to seven chemotherapeutic drugs in Coli, Proteus and Pseudomonas infections have changed in favour of increasing resistances of causative agents. The results obtained are an expression of the unstableness of antibiotic therapies under palliative purpose when urological basic diseases are not removed. From the analysis the demand for changing the general problems of obstructive pyelonephritis without possible operative sanation becomes evident. early diagnosis and treatment of predisposing factors are the two keystones of our efforts, when the chronic obstructive infection of the urinary tract by resistant causative agents shall not remain a therapeutic problem in the same measure as hitherto.
基于一项临床研究，对86例双侧梗阻性肾结石合并慢性梗阻性尿路感染患者进行了分析。为说明10年期间（1973 - 1982年）病原体耐药性的变化，对两个分开的5年分析进行了比较。结果表明，大肠杆菌、变形杆菌和假单胞菌感染中对七种化疗药物的敏感性关系发生了变化，病原体耐药性增加。所获得的结果表明，在未消除泌尿外科基础疾病的情况下，姑息性抗生素治疗不稳定。分析表明，对于无法进行手术治疗的梗阻性肾盂肾炎的一般问题进行改变的需求变得明显。当耐药病原体引起的慢性梗阻性尿路感染不应再像迄今为止那样成为一个治疗难题时，早期诊断和治疗易感因素是我们努力的两个关键。
