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Response to Letter to the Editor: Efficacy and Safety of Sintilimab Plus Pemetrexed and Platinum as First-Line Treatment for Locally Advanced or Metastatic Nonsquamous NSCLC: A Randomized, Double-Blind, Phase 3 Study (ORIENT-11).

作者信息

Yang Yunpeng, Zhou Hui, Zhang Li

机构信息

Medical Oncology Department, Sun Yat-sen University Cancer Center, State Key Laboratory of Oncology in South China, Collaborative Innovation Center for Cancer Medicine, Guangzhou, Guangdong, People's Republic of China.

Medical Science and Strategy Oncology, Innovent Biologics, Inc., Shanghai, People's Republic of China.

出版信息

J Thorac Oncol. 2020 Dec;15(12):e191-e192. doi: 10.1016/j.jtho.2020.09.028.

DOI:10.1016/j.jtho.2020.09.028
PMID:33246599
Abstract
摘要

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1
Response to Letter to the Editor: Efficacy and Safety of Sintilimab Plus Pemetrexed and Platinum as First-Line Treatment for Locally Advanced or Metastatic Nonsquamous NSCLC: A Randomized, Double-Blind, Phase 3 Study (ORIENT-11).致编辑的信的回复:信迪利单抗联合培美曲塞和铂类作为局部晚期或转移性非鳞状非小细胞肺癌一线治疗的疗效和安全性:一项随机、双盲、3期研究(ORIENT-11)
J Thorac Oncol. 2020 Dec;15(12):e191-e192. doi: 10.1016/j.jtho.2020.09.028.
2
Efficacy and Safety of Sintilimab Plus Pemetrexed and Platinum as First-Line Treatment for Locally Advanced or Metastatic Nonsquamous NSCLC: a Randomized, Double-Blind, Phase 3 Study (Oncology pRogram by InnovENT anti-PD-1-11).信迪利单抗联合培美曲塞和铂类化疗作为局部晚期或转移性非鳞状 NSCLC 患者一线治疗的有效性和安全性:一项随机、双盲、III 期研究(创新抗肿瘤 PD-1-11 研究)。
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3
Final overall survival data of sintilimab plus pemetrexed and platinum as First-Line treatment for locally advanced or metastatic nonsquamous NSCLC in the Phase 3 ORIENT-11 study.ORIENT-11 研究中,信迪利单抗联合培美曲塞和铂类化疗作为局部晚期或转移性非鳞状 NSCLC 患者一线治疗的最终总生存数据。
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Sintilimab Plus Platinum and Gemcitabine as First-Line Treatment for Advanced or Metastatic Squamous NSCLC: Results From a Randomized, Double-Blind, Phase 3 Trial (ORIENT-12).信迪利单抗联合铂类和吉西他滨作为晚期或转移性鳞状非小细胞肺癌的一线治疗:一项随机、双盲、3期试验(ORIENT-12)的结果
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Generalizability of ORIENT-11 trial results to a US standard-of-care cohort with advanced non-small-cell lung cancer.ORIENT-11试验结果对美国晚期非小细胞肺癌标准治疗队列的可推广性。
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Updated Analysis From KEYNOTE-189: Pembrolizumab or Placebo Plus Pemetrexed and Platinum for Previously Untreated Metastatic Nonsquamous Non-Small-Cell Lung Cancer.KEYNOTE-189 更新分析:帕博利珠单抗或安慰剂联合培美曲塞和铂类化疗用于未经治疗的转移性非鳞状非小细胞肺癌。
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引用本文的文献

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Research progress of sintilimab in the treatment of cancer (Review).信迪利单抗治疗癌症的研究进展(综述)
Oncol Lett. 2025 Mar 21;29(5):240. doi: 10.3892/ol.2025.14986. eCollection 2025 May.
2
Baseline tumour vessel perfusion as a non-invasive predictive biomarker for immune checkpoint therapy in non-small-cell lung cancer.基线肿瘤血管灌注作为非小细胞肺癌免疫检查点治疗的一种非侵入性预测生物标志物。
BMJ Oncol. 2024 Aug 21;3(1):e000473. doi: 10.1136/bmjonc-2024-000473. eCollection 2024.
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Pembrolizumab versus sintilimab in patients with advanced NSCLC: a retrospective multicenter study with propensity-score matching analysis.
帕博利珠单抗与信迪利单抗治疗晚期非小细胞肺癌患者的疗效对比:一项倾向评分匹配分析的回顾性多中心研究
Front Oncol. 2024 Dec 5;14:1422039. doi: 10.3389/fonc.2024.1422039. eCollection 2024.
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Camrelizumab plus carboplatin and pemetrexed as first-line therapy for advanced non-squamous non-small-cell lung cancer: 5-year outcomes of the CameL randomized phase 3 study.卡瑞利珠单抗联合卡铂和培美曲塞一线治疗晚期非鳞状非小细胞肺癌:CameL 随机 3 期研究的 5 年结果。
J Immunother Cancer. 2024 Nov 27;12(11):e009240. doi: 10.1136/jitc-2024-009240.
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Safety and efficacy of sintilimab combination therapy for the treatment of 48 patients with advanced malignant tumors.信迪利单抗联合疗法治疗48例晚期恶性肿瘤患者的安全性和有效性
Transl Cancer Res. 2022 Jan;11(1):252-261. doi: 10.21037/tcr-22-54.
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MedComm (2020). 2021 Dec 14;2(4):692-729. doi: 10.1002/mco2.105. eCollection 2021 Dec.
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Research progress in immune checkpoint inhibitors for lung cancer in China.中国肺癌免疫检查点抑制剂的研究进展
Ther Adv Med Oncol. 2021 Jul 20;13:17588359211029826. doi: 10.1177/17588359211029826. eCollection 2021.