Electrophysiologic responses and adenylate cyclase activities of mouse spinal cord-dorsal root ganglion explants rendered tolerant by chronic exposure to morphine or pertussis toxin. - Suppr | 超能文献

Electrophysiologic responses and adenylate cyclase activities of mouse spinal cord-dorsal root ganglion explants rendered tolerant by chronic exposure to morphine or pertussis toxin.

作者信息

Crain S M, Makman M H

机构信息

Department of Neuroscience, Albert Einstein College of Medicine, Yeshiva University, Bronx, New York.

出版信息

Adv Exp Med Biol. 1987;221:331-44. doi: 10.1007/978-1-4684-7618-7_23.

DOI:10.1007/978-1-4684-7618-7_23

Abstract

摘要

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Electrophysiologic responses and adenylate cyclase activities of mouse spinal cord-dorsal root ganglion explants rendered tolerant by chronic exposure to morphine or pertussis toxin.

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Pertussis toxin blocks depressant effects of opioid, monoaminergic and muscarinic agonists on dorsal-horn network responses in spinal cord-ganglion cultures.百日咳毒素可阻断阿片类、单胺能和毒蕈碱能激动剂对脊髓神经节培养物中背角网络反应的抑制作用。

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Pertussis toxin treatment results in tolerance to the depressant effects of opioid, monoaminergic, and muscarinic agonists on dorsal-horn network responses in mouse spinal cord-ganglion cultures.

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Modulation of adenylate cyclase activity of mouse spinal cord-ganglion explants by opioids, serotonin and pertussis toxin.阿片类物质、5-羟色胺和百日咳毒素对小鼠脊髓神经节外植体腺苷酸环化酶活性的调节作用

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Cyclic AMP or forskolin rapidly attenuates the depressant effects of opioids on sensory-evoked dorsal-horn responses in mouse spinal cord-ganglion explants.环磷酸腺苷（cAMP）或福司可林能迅速减弱阿片类药物对小鼠脊髓神经节外植体中感觉诱发的背角反应的抑制作用。

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Direct coupling of opioid receptors to both stimulatory and inhibitory guanine nucleotide-binding proteins in F-11 neuroblastoma-sensory neuron hybrid cells.阿片受体与F-11神经母细胞瘤-感觉神经元杂交细胞中刺激性和抑制性鸟嘌呤核苷酸结合蛋白的直接偶联。

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Maturation of opioid sensitivity of fetal mouse dorsal root ganglion neuron perikarya in organotypic cultures: regulation by spinal cord.器官型培养中胎鼠背根神经节神经元胞体阿片样物质敏感性的成熟：脊髓的调节作用

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Acute and chronic opiate-regulation of adenylate cyclase in brain: specific effects in locus coeruleus.脑内腺苷酸环化酶的急性和慢性阿片类调节：对蓝斑核的特异性作用

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Antibodies which recognize the C-terminus of the inhibitory guanine-nucleotide-binding protein (Gi) demonstrate that opioid peptides and foetal-calf serum stimulate the high-affinity GTPase activity of two separate pertussis-toxin substrates.识别抑制性鸟嘌呤核苷酸结合蛋白（Gi）C端的抗体表明，阿片肽和胎牛血清可刺激两种不同百日咳毒素底物的高亲和力GTP酶活性。

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Development of cross-tolerance to 5-hydroxytryptamine in organotypic cultures of mouse spinal cord-ganglia during chronic exposure to morphine.在长期暴露于吗啡的情况下，小鼠脊髓神经节器官型培养物中对5-羟色胺产生交叉耐受性的发展。

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