循环缓激肽在大鼠急性血管紧张素转换酶抑制所致血压反应中不起作用。
Lack of a role of circulating bradykinin in the blood pressure response to acute angiotensin converting enzyme inhibition in rats.
作者信息
Aubert J F, Waeber B, Nussberger J, Vavrek R, Stewart J M, Brunner H R
机构信息
Division of Nephrology and Hypertension, Centre Hospitalier Universitaire, Lausanne, Switzerland.
出版信息
Agents Actions Suppl. 1987;22:349-54.
The role of circulating bradykinin in blood pressure regulation was investigated in conscious normotensive rats using a competitive antagonist of bradykinin. The acute blood pressure effect of this antagonist was also evaluated after inhibition of angiotensin converting enzyme with captopril and during simultaneous infusion of exogenous angiotensin II. No evidence was found for a role of circulating bradykinin in rats studied under normal conditions. Endogenous bradykinin seemed however involved in blood pressure control during angiotensin II infusion. Acute angiotensin converting enzyme inhibition had no influence on the blood pressure response to the bradykinin antagonist.
使用缓激肽竞争性拮抗剂，在清醒的正常血压大鼠中研究了循环缓激肽在血压调节中的作用。在使用卡托普利抑制血管紧张素转换酶后以及同时输注外源性血管紧张素II期间，还评估了该拮抗剂的急性血压效应。在正常条件下研究的大鼠中，未发现循环缓激肽起作用的证据。然而，内源性缓激肽似乎在输注血管紧张素II期间参与血压控制。急性血管紧张素转换酶抑制对缓激肽拮抗剂的血压反应没有影响。
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