卡拉奇癌症登记处（KCR）：巴基斯坦特大城市按年龄组和性别划分的年龄标准化发病率。
Karachi Cancer Registry (KCR): Age-Standardized Incidence Rate by Age-Group and Gender in a Mega City of Pakistan.
机构信息
Department of Pathology & Laboratory Medicine, Aga Khan University Hospital, Karachi, Pakistan.
Jinnah Postgraduate Medical Centre, Karachi, Pakistan.
出版信息
Asian Pac J Cancer Prev. 2020 Nov 1;21(11):3251-3258. doi: 10.31557/APJCP.2020.21.11.3251.
OBJECTIVES
To estimate the cancer incidence by age group and gender for the population of Karachi Division by analyzing the Karachi Cancer Registry data of 2017-19.
SETTINGS
The population of Karachi division is 16.1 million according to national census 2017. 'Karachi Cancer Registry' which is a part of 'National Cancer Registry' is collecting data from eight major hospitals in Karachi since 2017. For outcome measures, cancer counts and the age standardized incidence rates (ASIR) per 100,000 population were computed for age groups (0-14, 15-19 and ≥20 years), in both genders and all cancer site/type.
METHODS
The population denominators were based on the population of Karachi division estimated at 16.1 million in the population census, 2017. Counts and age-standardized incidence rates (ASIR) were calculated for each of the three age categories.
RESULTS
From Jan 2017 till Dec 2019 a total of 33,309 malignant cases were recorded in KCR database comprising 17,490 (52.5%) females and 15,819 (47.5%) males. ASIRs in age groups 0-14, 15-19 and ≥ 20 years, among female were 11.5, 2.4 and 223.6 and in males were 17.6, 3.2 and 216.7 respectively. The commonest diagnosis in children, adolescent and adults were (1) among females: children; bone (3.12), leukemia (2.09) brain/CNS (1.26); in adolescents: bone (0.78), brain/CNS (0.27), connective and soft tissue (0.11), in adults: breast cancer (76.07), oral cancer (16.68) and ovary (10.89) respectively, and (2) among males: children; bone (4.56), leukemia (2.79) and brain/CNS (1.88); in adolescent; bone (1.19), brain/CNS (0.31) and leukemia (0.21) and in adults: oral cancer (42.83), liver (16.10) and bone (13.37) respectively.
CONCLUSION
Oral Cancer, a largely preventable cancer is the leading cancer in Karachi adult males while in female adults Breast Cancer is the leading cancer followed by Oral Cancer. In children and adolescents Bone, Leukemia and Brain/CNS malignancies are most common.
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目的
通过分析 2017-19 年卡拉奇癌症登记处的数据，估计卡拉奇分部的人口按年龄组和性别划分的癌症发病率。
地点
根据 2017 年全国人口普查，卡拉奇分部的人口为 1610 万。自 2017 年以来，“卡拉奇癌症登记处”（国家癌症登记处的一部分）一直在卡拉奇的 8 家主要医院收集数据。对于结局指标，计算了每个年龄组（0-14 岁、15-19 岁和≥20 岁）、两性和所有癌症部位/类型的癌症计数和年龄标准化发病率（ASIR）。
方法
人口分母基于 2017 年人口普查中估计的卡拉奇分部人口 1610 万。计算了每个三个年龄组的病例数和年龄标准化发病率（ASIR）。
结果
2017 年 1 月至 2019 年 12 月，KCR 数据库共记录了 33309 例恶性肿瘤病例，其中女性 17490 例（52.5%），男性 15819 例（47.5%）。0-14 岁、15-19 岁和≥20 岁年龄组女性的 ASIR 分别为 11.5、2.4 和 223.6，男性分别为 17.6、3.2 和 216.7。儿童、青少年和成年人中最常见的诊断是：（1）女性：儿童；骨（3.12），白血病（2.09）脑/中枢神经系统（1.26）；青少年：骨（0.78），脑/中枢神经系统（0.27），结缔组织和软组织（0.11），成年人：乳腺癌（76.07），口腔癌（16.68）和卵巢癌（10.89）；（2）男性：儿童；骨（4.56），白血病（2.79）和脑/中枢神经系统（1.88）；青少年；骨（1.19），脑/中枢神经系统（0.31）和白血病（0.21），成年人：口腔癌（42.83），肝癌（16.10）和骨癌（13.37）。
结论
口腔癌是一种在很大程度上可以预防的癌症，是卡拉奇成年男性中最主要的癌症，而在成年女性中，乳腺癌是最主要的癌症，其次是口腔癌。在儿童和青少年中，骨骼、白血病和脑/中枢神经系统恶性肿瘤最为常见。
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