Vellore EEG Center, Gwalior, Madhya Pradesh, India.
Department of Physiology, All India Institute of Medical Sciences, Bhubaneswar, Odisha, India.
World Neurosurg. 2021 Feb;146:210-214. doi: 10.1016/j.wneu.2020.11.099. Epub 2020 Nov 26.
Drug-resistant epilepsy accounts for approximately one third of all epilepsy cases; yet its exact etiopathogenesis still remains under intense exploration. Several factors have been advocated for predicting drug resistance in patients with epilepsy. Obstructive sleep apnea (OSA) is a commonly prevalent sleep disorder that exhibits a bidirectional and strong comorbidity with epilepsy. The exact pathophysiology of this comorbidity is not yet clearly explained. This study analyzes the relationship between drug-resistant epilepsy and OSA, and the findings indicate a strong role of rapid eye movement sleep (REMS) in the pathogenesis of this relationship. It also emerges from the study that REMS reduction is a prominent feature of OSA, and drug resistance in patients with epilepsy and treatment of OSA has been shown to restore REMS in several studies with concomitant improvement in seizure control.
耐药性癫痫约占所有癫痫病例的三分之一；然而，其确切的病因仍然在深入研究中。有几个因素被认为可以预测癫痫患者的耐药性。阻塞性睡眠呼吸暂停（OSA）是一种常见的睡眠障碍，与癫痫呈双向强共病关系。这种共病的确切病理生理学尚未得到明确解释。本研究分析了耐药性癫痫与 OSA 之间的关系，研究结果表明快速眼动睡眠（REMS）在这种关系的发病机制中起重要作用。研究还表明，REMS 减少是 OSA 的一个突出特征，几项研究表明，治疗 OSA 可恢复 REMS，同时改善癫痫发作的控制。
