Department of Genetics and Pathology, International Hereditary Cancer Center, Pomeranian Medical University in Szczecin, ul. Unii Lubelskiej 1, 71-252 Szczecin, Poland.
Department of Molecular Genetics and Epigenetics, Nofer Institute of Occupational Medicine, ul.św. Teresy od Dzieciątka Jezus 8, 91-348 Łódź, Poland.
J Trace Elem Med Biol. 2021 Mar;64:126682. doi: 10.1016/j.jtemb.2020.126682. Epub 2020 Nov 12.
We assessed whether blood cadmium levels were associated with incident lung cancer and could be used in the context of a screening program for early-stage lung cancer.
We measured blood cadmium levels among 205 lung cancer patients and 205 matched controls. Cases and controls were matched for sex, age and smoking history (total pack-years, years since cessation for former smokers).
The odds ratio for those in the highest quartile of cadmium level (versus lowest) was four-fold (OR = 4.41, 95 % CI:2.01-9.67, p < 0.01). The association was present in former smokers (OR = 16.8, 95 % CI:3.96-71.2, p < 0.01), but not in current smokers (OR = 1.23, 95 % CI: 0.34-4.38) or in never smokers (OR not defined). Among former smokers, the association was present in both early- and late-stage lung cancer.
Blood cadmium levels may be a marker to help with the early detection of lung cancer among former smokers.
我们评估了血液中镉水平是否与肺癌的发生有关，并能否在早期肺癌筛查项目中应用。
我们测量了 205 例肺癌患者和 205 例匹配对照者的血液镉水平。病例和对照者在性别、年龄和吸烟史（总吸烟包年数、已戒烟者的戒烟年限）方面进行匹配。
与镉水平最低四分位数相比，镉水平最高四分位数者的比值比为 4 倍（OR=4.41，95%CI：2.01-9.67，p<0.01）。这种关联在前吸烟者中存在（OR=16.8，95%CI：3.96-71.2，p<0.01），但在当前吸烟者（OR=1.23，95%CI：0.34-4.38）或从不吸烟者（OR 未定义）中不存在。在前吸烟者中，这种关联在早、晚期肺癌中均存在。
血液镉水平可能是帮助早期发现前吸烟者肺癌的标志物。
