血液中镉水平作为早期肺癌检测的标志物。

Blood cadmium levels as a marker for early lung cancer detection.

机构信息

Department of Genetics and Pathology, International Hereditary Cancer Center, Pomeranian Medical University in Szczecin, ul. Unii Lubelskiej 1, 71-252 Szczecin, Poland.

Department of Molecular Genetics and Epigenetics, Nofer Institute of Occupational Medicine, ul.św. Teresy od Dzieciątka Jezus 8, 91-348 Łódź, Poland.

出版信息

J Trace Elem Med Biol. 2021 Mar;64:126682. doi: 10.1016/j.jtemb.2020.126682. Epub 2020 Nov 12.

DOI:10.1016/j.jtemb.2020.126682

PMID:33249371

Abstract

BACKGROUND

We assessed whether blood cadmium levels were associated with incident lung cancer and could be used in the context of a screening program for early-stage lung cancer.

MATERIAL AND METHODS

We measured blood cadmium levels among 205 lung cancer patients and 205 matched controls. Cases and controls were matched for sex, age and smoking history (total pack-years, years since cessation for former smokers).

RESULTS

The odds ratio for those in the highest quartile of cadmium level (versus lowest) was four-fold (OR = 4.41, 95 % CI:2.01-9.67, p < 0.01). The association was present in former smokers (OR = 16.8, 95 % CI:3.96-71.2, p < 0.01), but not in current smokers (OR = 1.23, 95 % CI: 0.34-4.38) or in never smokers (OR not defined). Among former smokers, the association was present in both early- and late-stage lung cancer.

CONCLUSION

Blood cadmium levels may be a marker to help with the early detection of lung cancer among former smokers.

摘要

背景

我们评估了血液中镉水平是否与肺癌的发生有关，并能否在早期肺癌筛查项目中应用。

材料和方法

我们测量了 205 例肺癌患者和 205 例匹配对照者的血液镉水平。病例和对照者在性别、年龄和吸烟史（总吸烟包年数、已戒烟者的戒烟年限）方面进行匹配。

结果

与镉水平最低四分位数相比，镉水平最高四分位数者的比值比为 4 倍（OR=4.41，95%CI：2.01-9.67，p<0.01）。这种关联在前吸烟者中存在（OR=16.8，95%CI：3.96-71.2，p<0.01），但在当前吸烟者（OR=1.23，95%CI：0.34-4.38）或从不吸烟者（OR 未定义）中不存在。在前吸烟者中，这种关联在早、晚期肺癌中均存在。