Clinical characteristics and prognostic study of adult acute myeloid leukemia patients with mutations.

: A total of 156 adult acute myeloid leukemia (AML) patients were enrolled in this study to explore the clinical characteristics and prognostic impact of mutations. : Clinical characteristics, prognostic impact and the association between mutations and some other mutations were analyzed. : We found mutations were most frequently found in M5 subtype and intermediate risk karyotype and were correlated with , and mutations. A total of 145 patients were included in prognostic analysis; results showed mutations had no impact on OS and DFS. In normal karyotype-AML (CN-AML) and older (≥60 years) AML, mutations showed adverse impact on OS ( = 0.022;  = 0.019, respectively) and showed adverse prognostic tendency on DFS ( = 0.173;  = 0.108, respectively). mutations were also independent unfavourable prognostic factors for OS on CN-AML and older (≥60 years) AML patients and unfavourable factors for DFS on older (≥60 years) AML in multivariate analysis. Results also indicated that though mutations were associated with , and mutations, when coinciding with mutations, the prognosis of AML was not significantly impacted. : The reliability of our results need to be further confirmed by prospective randomized controlled studies covering a large numbers of AML patients. : The results showed mutations may act as a poor prognostic index especially in elder AML and CN-AML patients.