Jha Shilpy, Mitra Suvradeep, Patra Susama, Sethi Pruthwiraj, Jena Saubhagya K
Int J Gynecol Pathol. 2021 Nov 1;40(6):617-620. doi: 10.1097/PGP.0000000000000733.
Sertoli-Leydig cell tumor of the ovary with heterologous differentiation is a relatively uncommon tumor that occurs in females of variable age range. Krukenberg tumor (KT) is a relatively more common tumor of the ovary although only a few cases of KT occur during pregnancy making it an equally uncommon tumor in this setting. We received a unilateral ovarian mass in a 25-yr-old primigravida which we reported as Sertoli-Leydig cell tumor with heterologous (intestinal) differentiation based on its clinical and histomorphologic features. However, on further investigation, a gastric mass was found which was a signet-ring cell adenocarcinoma. We rectified our diagnosis of ovarian mass as KT. We retrospectively analyzed the reasons for our mistake and concluded that the rarity coupled with the nonclassic clinical features and histomorphology of KT during pregnancy pose challenges to the correct diagnosis. This report highlights the diagnostic challenges faced by us along with the ways to circumvent them in the future.
具有异源性分化的卵巢支持-间质细胞瘤是一种相对罕见的肿瘤,可发生于不同年龄段的女性。库肯勃瘤(KT)是一种相对更常见的卵巢肿瘤,尽管孕期发生KT的病例较少,使其在此情况下同样属于罕见肿瘤。我们接诊了一名25岁初产妇的单侧卵巢肿物,根据其临床和组织形态学特征,我们将其报告为具有异源性(肠型)分化的支持-间质细胞瘤。然而,进一步检查发现一个胃肿物,为印戒细胞腺癌。我们将卵巢肿物的诊断修正为KT。我们回顾性分析了误诊原因,得出结论:孕期KT的罕见性、非典型临床特征及组织形态学给正确诊断带来了挑战。本报告强调了我们所面临的诊断挑战以及未来规避这些挑战的方法。