经上皮准分子激光角膜切削术的疗效、安全性和可预测性：荟萃分析。

Efficacy, safety, and predictability of transepithelial photorefractive keratectomy: meta-analysis.

机构信息

From the Department of Ophthalmology, Saarland University Medical Center, Homburg/Saar, Germany (Sabau, Daas, Flockerzi, Seitz); Medical Biometrics, Epidemiology and Health Informatics Institute, Homburg/Saar, Germany (Behkit, Wagenpfeil); Institute of Experimental Ophthalmology, Saarland University, Homburg/Saar, Germany (Langenbucher); Department of Ophthalmology, Medical University of Graz, Graz, Austria (Ardjomand).

出版信息

J Cataract Refract Surg. 2021 May 1;47(5):634-640. doi: 10.1097/j.jcrs.0000000000000487.

DOI:10.1097/j.jcrs.0000000000000487

PMID:33252562

Abstract

PURPOSE

To evaluate the efficacy, safety, and predictability of transepithelial photorefractive keratectomy (TransPRK) for correcting myopia, astigmatism, and hyperopia.

SETTING

Department of Ophthalmology, Saarland University Medical Center, Homburg/Saar, Germany.

DESIGN

Meta-analysis of retrospective or prospective studies.

METHODS

Relevant studies were collected from Medline and included when meeting the following predefined criteria: randomized controlled trials, at least 1 of the main outcome measures as efficacy, safety, or predictability, and 1 common TransPRK laser (Schwind Amaris). The parameters estimates and 95% CI were derived from random-effects meta-analysis to account for possible heterogeneity.

RESULTS

Because hyperopia studies did not meet the inclusion criteria, the results are centered on myopia and astigmatism. Sixteen studies with a total of 1924 treated eyes were included in the meta-analysis. The mean efficacy, safety, and predictability had a probability of 94% (CI, 0.86-0.97), 0% (CI, 0.00-0.03), and 89% (CI, 0.82-0.93), respectively. The mean correction index, difference vector, and index of success had a value of 1.01 (CI, 1.01-1.02), 0.20 (CI, 0.06-0.34), and 0.12 (CI, 0.07-0.18), respectively.

CONCLUSIONS

This summary estimate showed that TransPRK was highly effective, safe, and predictable in correcting myopia and/or astigmatism.

摘要

目的

评估经上皮准分子激光角膜切削术（TransPRK）矫正近视、散光和远视的疗效、安全性和可预测性。

地点

德国萨尔兰大学医学中心眼科。

设计

回顾性或前瞻性研究的荟萃分析。

方法

从 Medline 收集相关研究，并在符合以下预设标准的情况下纳入：随机对照试验，主要结局指标至少有 1 个为疗效、安全性或可预测性，且使用 1 种常见的 TransPRK 激光（Schwind Amaris）。参数估计值和 95%置信区间采用随机效应荟萃分析得出，以考虑可能的异质性。

结果

由于远视研究不符合纳入标准，因此结果主要集中在近视和散光上。荟萃分析共纳入 16 项研究，共计 1924 只治疗眼。平均疗效、安全性和可预测性的概率分别为 94%（CI，0.86-0.97）、0%（CI，0.00-0.03）和 89%（CI，0.82-0.93）。平均矫正指数、差异向量和成功率指数分别为 1.01（CI，1.01-1.02）、0.20（CI，0.06-0.34）和 0.12（CI，0.07-0.18）。