Centre of Health Sciences, Faculty of Health Sciences, University of the Faroe Islands, Tórshavn, Faroe Islands.
Department of Occupational Medicine and Public Health, The Faroese Hospital System, Tórshavn, Faroe Islands.
Clin Infect Dis. 2021 Dec 6;73(11):e4058-e4063. doi: 10.1093/cid/ciaa1792.
BACKGROUND: Little is known about long-term recovery from coronavirus disease 2019 (COVID-19) disease, especially in nonhospitalized individuals. In this longitudinal study we present symptoms registered during the acute phase as well as long COVID (ie, long-lasting COVID-19 symptoms) in patients from the Faroe Islands. METHODS: All consecutive patients with confirmed reverse transcription-polymerase chain reaction testing from April to June 2020 were invited to participate in this study for the assessment of long COVID. Demographic and clinical characteristics and self-reported acute and persistent symptoms were assessed using a standardized detailed questionnaire administered at enrollment and at repeated phone interviews in the period 22 April to 16 August. RESULTS: Of the 180 participants (96.3% of the 187 eligible COVID-19 patients), 53.1% reported persistence of at least 1 symptom after a mean of 125 days after symptoms onset, 33.0% reported 1 or 2 symptoms, and 20.1% reported 3 or more symptoms. At the last follow-up, 46.9% were asymptomatic compared with 4.4% during the acute phase. The most prevalent persistent symptoms were fatigue, loss of smell and taste, and arthralgias. CONCLUSIONS: Our results show that it might take months for symptoms to resolve, even among nonhospitalized persons with mild illness course in the acute phase. Continued monitoring for long COVID is needed.
背景:对于新冠肺炎(COVID-19)疾病的长期康复,特别是在非住院患者中,人们知之甚少。在这项纵向研究中,我们介绍了法罗群岛患者在急性阶段记录的症状以及长新冠(即 COVID-19 长期症状)。
方法:我们邀请了 2020 年 4 月至 6 月期间所有经逆转录聚合酶链反应检测确诊的连续患者参与这项研究,以评估长新冠。使用标准化详细问卷评估人口统计学和临床特征以及自我报告的急性和持续症状,该问卷在登记时和 2020 年 4 月 22 日至 8 月 16 日期间的重复电话访谈中进行。
结果:在 180 名参与者中(COVID-19 患者中 187 名合格患者的 96.3%),53.1%报告在症状出现后平均 125 天至少有 1 种症状持续存在,33.0%报告有 1 或 2 种症状,20.1%报告有 3 种或更多症状。在最后一次随访时,与急性阶段的 4.4%相比,46.9%的患者无症状。最常见的持续症状是疲劳、嗅觉和味觉丧失以及关节痛。
结论:我们的研究结果表明,即使在急性阶段病情较轻的非住院患者中,症状也可能需要数月才能缓解。需要对长新冠进行持续监测。
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