[患有正在发展的劳斯氏白血病的小鼠针对群特异性逆转录病毒抗原的抗淋巴细胞体液自身免疫反应]
[Antilymphocytic humoral autoimmune response of mice with developing Rauscher leukemia directed against group-specific retrovirus antigens].
作者信息
Ter-Grigorov V S, Graf I A, Pivnik A V, Etkin A F, Moskovkina O Ia
出版信息
Eksp Onkol. 1987;9(6):48-51.
The methods of indirect membrane immunofluorescence, immunoenzyme analysis, complement-dependent cytotoxicity and sorption tests were used to demonstrate two types of humoral antilymphocytic autoimmune reactions at the early stage of the Rauscher leukemia in mice of BALB/c, BDF1 and C57B1/6 strains. The first one is directed against group-specific oncoviral antigens (p30, p15) expressed on the lymphocyte membrane of both intact mice and of those with leukemia, the second one is virus-independent and possesses strain specificity.
采用间接膜免疫荧光法、免疫酶分析法、补体依赖细胞毒性法和吸附试验，在BALB/c、BDF1和C57B1/6品系小鼠的劳舍尔白血病早期，证实了两种体液抗淋巴细胞自身免疫反应。第一种针对完整小鼠和白血病小鼠淋巴细胞膜上表达的组特异性肿瘤病毒抗原（p30、p15），第二种与病毒无关，具有品系特异性。
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