英国阿片类药物流行现状及慢性疼痛治疗优化策略。
Current status of opioid epidemic in the United Kingdom and strategies for treatment optimisation in chronic pain.
机构信息
School of Pharmacy, University of Birmingham, Birmingham, B15 2TT, UK.
出版信息
Int J Clin Pharm. 2021 Apr;43(2):318-322. doi: 10.1007/s11096-020-01205-y. Epub 2020 Nov 30.
Abstract
The increase in opioid prescriptions in the United States has been accompanied by an increase in misuse as well as overdose and toxicity related morbidity and mortality. However, the extent of the increased opioid use, including misuse in the United Kingdom, currently remains less debated. Recent studies in the United Kingdom have shown a rise in opioid use and attributed deaths, particularly in areas with higher deprivation. There are also large variations amongst the devolved nations; Scotland has the highest drug-related deaths and year-on-year increase within Europe. Better clinical guidelines that can enable person-centred management of chronic pain, medicines optimisation, and early diagnosis and treatment of opioid use disorder are crucial to addressing opioid-related morbidity and mortality in the United Kingdom.
摘要
在美国，阿片类药物处方的增加伴随着误用以及与过量和毒性相关的发病率和死亡率的增加。然而，目前仍较少有争议的是英国阿片类药物使用增加的程度，包括误用。英国最近的研究表明，阿片类药物的使用和归因死亡有所增加，特别是在贫困程度较高的地区。各分权国家之间也存在很大差异；苏格兰的药物相关死亡人数和欧洲范围内的年增长率最高。更好的临床指南，可以实现以患者为中心的慢性疼痛管理、药物优化以及阿片类药物使用障碍的早期诊断和治疗，这对于解决英国的阿片类药物相关发病率和死亡率至关重要。
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本文引用的文献
1
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2
Opioid-related deaths in Europe: Strategies for a comprehensive approach to address a major public health concern.
Int J Drug Policy. 2020 Feb;76:102616. doi: 10.1016/j.drugpo.2019.102616. Epub 2019 Dec 16.
3
Medicines associated with dependence or withdrawal: a mixed-methods public health review and national database study in England.
Lancet Psychiatry. 2019 Nov;6(11):935-950. doi: 10.1016/S2215-0366(19)30331-1. Epub 2019 Oct 3.
4
'If I die, I die, I don't care about my health': Perspectives on self-care of people experiencing homelessness.
Health Soc Care Community. 2020 Jan;28(1):160-172. doi: 10.1111/hsc.12850. Epub 2019 Sep 6.
5
Provision and accessibility of primary healthcare services for people who are homeless: a qualitative study of patient perspectives in the UK.
Br J Gen Pract. 2019 Aug;69(685):e526-e536. doi: 10.3399/bjgp19X704633. Epub 2019 Jul 15.
6
Multimorbidity and emergency department visits by a homeless population: a database study in specialist general practice.
Br J Gen Pract. 2019 Aug;69(685):e515-e525. doi: 10.3399/bjgp19X704609. Epub 2019 Jul 1.
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8
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9
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