King Abdulaziz Medical City, King Saud Bin Abdulaziz University for Health Sciences and King Abdullah International Medical Research Center, MNGHA, Riyadh, Saudi Arabia.
King Faisal Specialist Hospital and Research Center, Riyadh, Saudi Arabia.
Crit Rev Oncol Hematol. 2021 Jan;157:103144. doi: 10.1016/j.critrevonc.2020.103144. Epub 2020 Nov 7.
Management of stage III non- small cell lung cancer (NSCLC) is very challenging due to being a group of widely heterogeneous diseases that require multidisciplinary approaches with timely and coordinated care. The standards of care had significant changes over the last couple of years because of the introduction of consolidation therapy with checkpoint inhibitor following concurrent chemo-radiotherapy and the evolving new role of tyrosine kinase inhibitors in the adjuvant setting. The manuscript presents evidence-based recommendations for the workup, staging, treatment and follow up of the various subtypes of stage III NSCLC. The guidelines were developed by experts in various fields of thoracic oncology and guidelines development. The guidelines consider the sequence of interventions and the role of each discipline in the management of the disease taking into account the recent development and included required resources to help physicians provide better care.
由于 III 期非小细胞肺癌(NSCLC)是一组广泛异质性的疾病,需要多学科的方法,并及时协调护理,因此其管理极具挑战性。由于在同步放化疗后采用检查点抑制剂进行巩固治疗,以及酪氨酸激酶抑制剂在辅助治疗中的新作用不断发展,过去几年中治疗标准发生了重大变化。本文提出了基于证据的推荐意见,用于 III 期 NSCLC 各种亚型的检查、分期、治疗和随访。这些指南由胸肿瘤学各个领域的专家和指南制定者制定。这些指南考虑了干预措施的顺序以及每个学科在疾病管理中的作用,同时考虑了最新的发展,并包括了所需的资源,以帮助医生提供更好的护理。