Carrillo-Esper Raúl, Melgar-Bieberach Rebeca E, Jacinto-Flores Sarahi A, Tapia-Salazar Mauricio, Campa-Mendoza Ángela N
Centro Nacional de Investigación y Atención en Quemados, Instituto Nacional de Rehabilitación, Ciudad de México, México.
Cir Cir. 2020;88(6):787-793. doi: 10.24875/CIRU.20000416.
Infection with the SARS-CoV-2 virus and the development of all manifestations of COVID-19, predisposes to arterial and venous thromboembolic disease. The coagulation system can be activated by various viruses, including SARS-CoV-2. Vascular endothelial damage, added to the development of disseminated intravascular coagulation, affects the prognosis and mortality from this disease. Treatment is aimed at the prevention, early detection and timely interventions of all coagulation disorders generated by COVID-19. The recommended anticoagulant is low molecular weight heparin, taking into account creatinine clearance, and if major invasive procedures will be performed, unfractionated heparin is a safe option.
感染严重急性呼吸综合征冠状病毒2(SARS-CoV-2)病毒以及出现新型冠状病毒肺炎(COVID-19)的所有表现,均易引发动静脉血栓栓塞性疾病。凝血系统可被包括SARS-CoV-2在内的多种病毒激活。血管内皮损伤加上弥散性血管内凝血的发生,会影响该疾病的预后和死亡率。治疗旨在预防、早期发现并及时干预由COVID-19引发的所有凝血障碍。推荐使用低分子量肝素作为抗凝剂,需考虑肌酐清除率,若将进行大型侵入性操作,普通肝素是一种安全选择。