Department of Paediatrics, Olabisi Onabanjo University Teaching Hospital, Sagamu, Ogun, Nigeria.
Department of Paediatrics, Mercy Street Children Hospital, Lagos, Nigeria.
J Trop Pediatr. 2021 Jan 29;67(1). doi: 10.1093/tropej/fmaa095.
Significant morbidity and mortality in patients with sickle cell disease are accounted for by lung complications. To facilitate good respiratory care for children with sickle cell anaemia the generation of local predicted values is highly important.
To determine the reference equations for spirometry indices estimation in children with sickle cell anaemia, which can be readily used as proxy when there is no easy accessibility to spirometer.
A cross-sectional study with linear regression models developed to estimate reference values for spirometric indices in Nigerian children with sickle cell anaemia aged 5-12 years.
Age as independent variables for estimation of forced expiratory volume in 1 s (FEV1) was associated with lowest coefficient of determination (R2) and highest standard error. The coefficient of determination (R2) and standard error was highest and lowest, respectively, when arm span was used to determine peak expiratory flow rate (PEFR). Prediction models for PEFR and FEV1 gave the closest mean estimates that were 0.18 and 0.16 lower and higher than the actual mean PEFR and FEV1, respectively, but the differences was significant only in FEV1. On the contrary the prediction models for forced vital capacity (FVC) gave mean estimates that was 1.02 higher than the actual mean FVC, however, the finding was not significant.
Preferred proxy for spirometry indices in children with sickle cell anaemia may be arm span.
镰状细胞病患者的肺部并发症导致发病率和死亡率居高不下。为了方便对镰状细胞贫血儿童进行良好的呼吸护理，生成当地的预测值非常重要。
确定镰状细胞贫血儿童肺量计指标估计的参考方程，以便在无法轻易获得肺量计时作为替代。
本研究采用横断面研究，建立线性回归模型来估计尼日利亚 5-12 岁镰状细胞贫血儿童的肺量计指标参考值。
年龄作为估计 1 秒用力呼气量（FEV1）的独立变量，与最低决定系数（R2）和最高标准误差相关。使用臂展来确定呼气峰流速（PEFR）时，决定系数（R2）最高，标准误差最低。PEFR 和 FEV1 的预测模型给出了最接近的平均估计值，分别比实际平均 PEFR 和 FEV1低 0.18 和 0.16，但差异仅在 FEV1 中显著。相反，用力肺活量（FVC）的预测模型给出的平均估计值比实际平均 FVC 高 1.02，但这一发现没有统计学意义。
镰状细胞贫血儿童肺量计指标的首选替代指标可能是臂展。
