Ozkan A N, Hoyt D B, Ninnemann J L
Department of Surgery, University of California, San Diego 92103.
J Burn Care Rehabil. 1987 Nov-Dec;8(6):527-30.
Severe trauma is known to produce pathophysiologic changes leading to the generation of immunosuppressive compounds. With recent advances in biotechnology, a number of these factors have been identified and characterized. Many of these substances have been found to be degradation products of normal serum and tissue proteins. These degradation products have profound biologic activity both in vivo and in vitro. This report briefly focuses on a number of these factors and summarizes the current work involved in the determination of the identity and mechanisms of a previously reported suppressor-active peptide isolated from the serum of trauma patients.
已知严重创伤会产生导致免疫抑制化合物生成的病理生理变化。随着生物技术的最新进展，已鉴定并表征了其中一些因素。已发现许多这些物质是正常血清和组织蛋白的降解产物。这些降解产物在体内和体外均具有深远的生物学活性。本报告简要聚焦于其中一些因素，并总结了目前在确定从创伤患者血清中分离出的一种先前报道的具有抑制活性的肽的身份和作用机制方面所开展的工作。
