Platinum(II) Complexes with Bulky Disubstitute Triazolopyrimidines as Promising Materials for Anticancer Agents.

Herein, we present dicarboxylate platinum(II) complexes of the general formula [Pt(mal)(DMSO)(L)] and [Pt(CBDC)(DMSO)(L)], where L is dbtp 5,7-diutyl-1,2,4-triazolo[1,5-]pyrimidine) or ibmtp (7-isobutyl-5-methyl-1,2,4- triazolo[1,5-]pyrimidine), as prospective prodrugs. The platinum(II) complexes were synthesized in a one-pot reaction between -[PtCl(DMSO)], silver malonate or silver cyclobutane-1,1-dicarboxylate and triazolopyrimidines. All platinum(II) compounds were characterized by FT-IR, and H, C, N and Pt NMR; and their square planar geometries with one monodentate N(3)-bonded 5,7-disubstituted-1,2,4-triazolo[1,5-]pyrimidine, one S-bonded molecule of dimethyl sulfoxide and one O,O-chelating malonato (, ) or O,O-chelating cyclobutane-1,1-dicarboxylato (, ) was determined. Additionally, [Pt(CBDC)(dbtp)(DMSO)] () exhibited (i) substantial in vitro cytotoxicity against the lung adenocarcinoma epithelial cell line (A549) (IC = 5.00 µM) and the cisplatin-resistant human ductal breast epithelial tumor cell line (T47D) (IC = 6.60 µM); and (ii) definitely exhibited low toxicity against normal murine embryonic fibroblast cells (BALB/3T3).