• 文献检索
  • 文档翻译
  • 深度研究
  • 学术资讯
  • Suppr Zotero 插件Zotero 插件
  • 邀请有礼
  • 套餐&价格
  • 历史记录
应用&插件
Suppr Zotero 插件Zotero 插件浏览器插件Mac 客户端Windows 客户端微信小程序
定价
高级版会员购买积分包购买API积分包
服务
文献检索文档翻译深度研究API 文档MCP 服务
关于我们
关于 Suppr公司介绍联系我们用户协议隐私条款
关注我们

Suppr 超能文献

核心技术专利：CN118964589B侵权必究
粤ICP备2023148730 号-1Suppr @ 2026

文献检索

告别复杂PubMed语法，用中文像聊天一样搜索，搜遍4000万医学文献。AI智能推荐，让科研检索更轻松。

立即免费搜索

文件翻译

保留排版，准确专业，支持PDF/Word/PPT等文件格式，支持 12+语言互译。

免费翻译文档

深度研究

AI帮你快速写综述，25分钟生成高质量综述，智能提取关键信息，辅助科研写作。

立即免费体验

双头阳离子脂肽：一类新兴的抗菌剂。

Double-Headed Cationic Lipopeptides: An Emerging Class of Antimicrobials.

机构信息

Faculty of Chemistry, University of Gdansk, Wita Stwosza 63, 80-308 Gdansk, Poland.

Faculty of Pharmacy, Medicinal University of Gdansk, Al. Gen. J. Hallera 107, 80-416 Gdansk, Poland.

出版信息

Int J Mol Sci. 2020 Nov 25;21(23):8944. doi: 10.3390/ijms21238944.

DOI:10.3390/ijms21238944
PMID:33255674
原文链接:https://pmc.ncbi.nlm.nih.gov/articles/PMC7728077/
Abstract

Antimicrobial peptides (AMPs) constitute a promising tool in the development of novel therapeutic agents useful in a wide range of bacterial and fungal infections. Among the modifications improving pharmacokinetic and pharmacodynamic characteristics of natural AMPs, an important role is played by lipidation. This study focuses on the newly designed and synthesized lipopeptides containing multiple Lys residues or their shorter homologues with palmitic acid (C) attached to the side chain of a residue located in the center of the peptide sequence. The approach resulted in the development of lipopeptides representing a model of surfactants with two polar headgroups. The aim of this study is to explain how variations in the length of the peptide chain or the hydrocarbon side chain of an amino acid residue modified with C, affect biological functions of lipopeptides, their self-assembling propensity, and their mode of action.

摘要

抗菌肽 (AMPs) 是一种很有前途的工具，可用于开发针对各种细菌和真菌感染的新型治疗药物。在提高天然 AMPs 的药代动力学和药效学特性的修饰中，脂质化起着重要作用。本研究集中于新设计和合成的含有多个赖氨酸残基或其较短同源物的脂肽，这些残基带有棕榈酸 (C) 连接到肽序列中心残基的侧链上。这种方法开发了具有两个极性头基的表面活性剂模型的脂肽。本研究的目的是解释修饰后的氨基酸残基的肽链长度或碳氢侧链的变化如何影响脂肽的生物学功能、自组装倾向及其作用模式。

https://cdn.ncbi.nlm.nih.gov/pmc/blobs/591e/7728077/5cb12c918e1b/ijms-21-08944-g007.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/591e/7728077/3a2c1be0f06b/ijms-21-08944-g001.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/591e/7728077/ada86d875657/ijms-21-08944-g002.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/591e/7728077/4e0cf67d85cd/ijms-21-08944-g003.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/591e/7728077/f004e11831b2/ijms-21-08944-g004.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/591e/7728077/788059d57219/ijms-21-08944-g005.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/591e/7728077/e77c978bd572/ijms-21-08944-g006.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/591e/7728077/5cb12c918e1b/ijms-21-08944-g007.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/591e/7728077/3a2c1be0f06b/ijms-21-08944-g001.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/591e/7728077/ada86d875657/ijms-21-08944-g002.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/591e/7728077/4e0cf67d85cd/ijms-21-08944-g003.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/591e/7728077/f004e11831b2/ijms-21-08944-g004.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/591e/7728077/788059d57219/ijms-21-08944-g005.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/591e/7728077/e77c978bd572/ijms-21-08944-g006.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/591e/7728077/5cb12c918e1b/ijms-21-08944-g007.jpg

相似文献

1
Double-Headed Cationic Lipopeptides: An Emerging Class of Antimicrobials.双头阳离子脂肽：一类新兴的抗菌剂。
Int J Mol Sci. 2020 Nov 25;21(23):8944. doi: 10.3390/ijms21238944.
2
Hydrocarbon-stapled lipopeptides exhibit selective antimicrobial activity.烃链固定的脂肽具有选择性抗菌活性。
Biopolymers. 2017 May;108(3). doi: 10.1002/bip.23006.
3
Effect of self-assembly on antimicrobial activity of double-chain short cationic lipopeptides.自组装对双链短阳离子脂肽抗菌活性的影响。
Bioorg Med Chem. 2019 Dec 1;27(23):115129. doi: 10.1016/j.bmc.2019.115129. Epub 2019 Oct 17.
4
Biological and structural effects of the conjugation of an antimicrobial decapeptide with saturated, unsaturated, methoxylated and branched fatty acids.抗菌十肽与饱和、不饱和、甲氧基化和支链脂肪酸共轭的生物学和结构效应。
J Pept Sci. 2017 Jan;23(1):45-55. doi: 10.1002/psc.2958. Epub 2016 Dec 26.
5
Rationally designed antimicrobial peptides: Insight into the mechanism of eleven residue peptides against microbial infections.理性设计的抗菌肽：十一肽抗微生物感染机制的研究进展。
Biochim Biophys Acta Biomembr. 2020 Apr 1;1862(4):183177. doi: 10.1016/j.bbamem.2020.183177. Epub 2020 Jan 15.
6
Effect of Disulfide Cyclization of Ultrashort Cationic Lipopeptides on Antimicrobial Activity and Cytotoxicity.二硫键环化对超短阳离子脂肽抗菌活性和细胞毒性的影响。
Int J Mol Sci. 2020 Sep 29;21(19):7208. doi: 10.3390/ijms21197208.
7
Ultrashort Cationic Lipopeptides-Effect of -Terminal Amino Acid and Fatty Acid Type on Antimicrobial Activity and Hemolysis.超短阳离子脂肽-末端氨基酸和脂肪酸类型对抑菌活性和溶血的影响。
Molecules. 2020 Jan 8;25(2):257. doi: 10.3390/molecules25020257.
8
Trivalent ultrashort lipopeptides are potent pH dependent antifungal agents.三价超短类脂肽是一种有效的 pH 依赖性抗真菌剂。
J Med Chem. 2012 Feb 9;55(3):1296-302. doi: 10.1021/jm2014474. Epub 2012 Feb 1.
9
Investigating the antimicrobial peptide 'window of activity' using cationic lipopeptides with hydrocarbon and fluorinated tails.研究具有烃尾和氟尾的阳离子脂肽的抗菌肽“活性窗口”。
Int J Antimicrob Agents. 2012 Jul;40(1):36-42. doi: 10.1016/j.ijantimicag.2012.03.013. Epub 2012 May 10.
10
How do Self-Assembling Antimicrobial Lipopeptides Kill Bacteria?自组装抗菌脂肽如何杀死细菌？
ACS Appl Mater Interfaces. 2020 Dec 16;12(50):55675-55687. doi: 10.1021/acsami.0c17222. Epub 2020 Dec 1.

引用本文的文献

1
Self-assembled nanopeptide dendrites with high antifungal activity and protease hydrolytic stability for fungal keratitis treatment.具有高抗真菌活性和蛋白酶水解稳定性的自组装纳米肽树枝状分子用于真菌性角膜炎治疗。
J Nanobiotechnology. 2025 Aug 21;23(1):577. doi: 10.1186/s12951-025-03670-x.
2
Lipidation of Naturally Occurring α-Helical Antimicrobial Peptides as a Promising Strategy for Drug Design.天然α-螺旋抗菌肽的脂质化作为药物设计的一种有前途的策略。
Int J Mol Sci. 2023 Feb 16;24(4):3951. doi: 10.3390/ijms24043951.
3
Understanding the Role of Self-Assembly and Interaction with Biological Membranes of Short Cationic Lipopeptides in the Effective Design of New Antibiotics.

本文引用的文献

1
Aggregation determines the selectivity of membrane-active anticancer and antimicrobial peptides: The case of killerFLIP.聚集决定了膜活性抗癌和抗菌肽的选择性：以 killerFLIP 为例。
Biochim Biophys Acta Biomembr. 2020 Feb 1;1862(2):183107. doi: 10.1016/j.bbamem.2019.183107. Epub 2019 Oct 31.
2
Effect of self-assembly on antimicrobial activity of double-chain short cationic lipopeptides.自组装对双链短阳离子脂肽抗菌活性的影响。
Bioorg Med Chem. 2019 Dec 1;27(23):115129. doi: 10.1016/j.bmc.2019.115129. Epub 2019 Oct 17.
3
Influence of Short Cationic Lipopeptides with Fatty Acids of Different Chain Lengths on Bacterial Biofilms Formed on Polystyrene and Hydrogel Surfaces.
理解短阳离子脂肽的自组装及其与生物膜的相互作用在新型抗生素有效设计中的作用。
Antibiotics (Basel). 2022 Oct 27;11(11):1491. doi: 10.3390/antibiotics11111491.
4
Rationally Designed Antimicrobial Peptides Are Potential Tools to Combat Devastating Bacteria and Fungi.理性设计的抗菌肽是对抗破坏性细菌和真菌的潜在工具。
Int J Mol Sci. 2022 Jun 2;23(11):6244. doi: 10.3390/ijms23116244.
5
Thanatin: An Emerging Host Defense Antimicrobial Peptide with Multiple Modes of Action.Thanatin：一种具有多种作用机制的新兴宿主防御抗菌肽。
Int J Mol Sci. 2021 Feb 3;22(4):1522. doi: 10.3390/ijms22041522.
不同链长脂肪酸的短阳离子脂肽对在聚苯乙烯和水凝胶表面形成的细菌生物膜的影响。
Pharmaceutics. 2019 Oct 1;11(10):506. doi: 10.3390/pharmaceutics11100506.
4
A review of lipidation in the development of advanced protein and peptide therapeutics.脂质化在先进蛋白和肽类药物开发中的研究进展综述。
J Control Release. 2019 Feb 10;295:1-12. doi: 10.1016/j.jconrel.2018.12.032. Epub 2018 Dec 21.
5
Short arginine-rich lipopeptides: From self-assembly to antimicrobial activity.短精氨酸丰富的脂肽：从自组装到抗菌活性。
Biochim Biophys Acta Biomembr. 2018 Nov;1860(11):2242-2251. doi: 10.1016/j.bbamem.2018.09.004. Epub 2018 Sep 7.
6
Dilipid ultrashort cationic lipopeptides as adjuvants for chloramphenicol and other conventional antibiotics against Gram-negative bacteria.作为佐剂的二脂类超短阳离子脂肽与氯霉素和其他针对革兰氏阴性菌的传统抗生素联用。
Amino Acids. 2019 Mar;51(3):383-393. doi: 10.1007/s00726-018-2673-9. Epub 2018 Nov 3.
7
In Vitro Evaluation of Cytotoxicity and Permeation Study on Lysine- and Arginine-Based Lipopeptides with Proven Antimicrobial Activity.具有抗菌活性的赖氨酸和精氨酸基脂肽的体外细胞毒性和渗透研究。
Molecules. 2017 Dec 8;22(12):2173. doi: 10.3390/molecules22122173.
8
Structure and Interactions of A Host Defense Antimicrobial Peptide Thanatin in Lipopolysaccharide Micelles Reveal Mechanism of Bacterial Cell Agglutination.宿主防御性抗菌肽 Thanatin 在脂多糖胶束中的结构与相互作用揭示了细菌细胞聚集的机制。
Sci Rep. 2017 Dec 19;7(1):17795. doi: 10.1038/s41598-017-18102-6.
9
Peptide Lipidation - A Synthetic Strategy to Afford Peptide Based Therapeutics.肽的脂化修饰——一种制备基于肽的治疗药物的合成策略。
Adv Exp Med Biol. 2017;1030:185-227. doi: 10.1007/978-3-319-66095-0_9.
10
Synthesis and Surface Activity of Cationic Amino Acid-Based Surfactants in Aqueous Solution.阳离子氨基酸基表面活性剂在水溶液中的合成及表面活性
J Surfactants Deterg. 2017;20(5):1189-1196. doi: 10.1007/s11743-017-2002-4. Epub 2017 Jul 31.