Department of Management Sciences, Tamkang University, New Taipei 25137, Taiwan.
Department of Pathology & Laboratory Medicine, Taoyuan Armed Forces General Hospital, Taoyuan 32551, Taiwan.
Int J Environ Res Public Health. 2020 Nov 25;17(23):8763. doi: 10.3390/ijerph17238763.
This cross-sectional study aimed to compare risk factors for chronic kidney disease (CKD) in older adults with or without dyslipidemia and/or cardiovascular diseases (CVD) in Taipei City, Taiwan. The data on 2912 participants with hyperlipidemia and/or CVD and 14,002 healthy control participants derived from the Taipei City Elderly Health Examination Database (2010 to 2011) were analyzed. The associations between conventional CKD risk factors and CKD were comparable between participants with and without hyperlipidemia. Participants with high uric acid and BUN had a higher risk of CKD if they also had hyperlipidemia and CVD [odds ratio (OR) in uric acid = 1.572, 95% CI 1.186-2.120, < 0.05; OR in BUN = 1.271, 95% CI 1.181-1.379, < 0.05]. The effect was smaller in participants with hyperlipidemia only (OR in uric acid = 1.291, 95% CI 1.110-1.507, < 0.05; OR in BUN = 1.169, 95% CI 1.122-1.221, < 0.05). The association between uric acid/BUN and CKD was also observed in the healthy population and participants with CVD only. In conclusion, older adults with hyperlipidemia and CVD are at high of CKD. Physicians should be alert to the potential for CKD in older patients with hyperlipidemia and CVD.
本横断面研究旨在比较台湾台北市伴有或不伴有血脂异常和/或心血管疾病（CVD）的老年患者发生慢性肾脏病（CKD）的危险因素。分析了来源于台北市老年健康检查数据库（2010 至 2011 年）的 2912 例高脂血症和/或 CVD 患者和 14002 例健康对照者的数据。伴有和不伴有高脂血症的参与者之间，传统 CKD 危险因素与 CKD 之间的相关性相似。如果同时伴有高脂血症和 CVD，尿酸和 BUN 较高的患者发生 CKD 的风险更高[尿酸的比值比（OR）=1.572，95%可信区间（CI）为 1.186-2.120， < 0.05；BUN 的 OR=1.271，95% CI 为 1.181-1.379， < 0.05]。在仅有高脂血症的患者中，作用较小（尿酸的 OR=1.291，95% CI 为 1.110-1.507， < 0.05；BUN 的 OR=1.169，95% CI 为 1.122-1.221， < 0.05）。尿酸/BUN 与 CKD 的相关性也在健康人群和仅有 CVD 的患者中观察到。总之，患有高脂血症和 CVD 的老年患者发生 CKD 的风险较高。医生应警惕高脂血症和 CVD 老年患者发生 CKD 的可能性。
Zotero 插件