Chan Gloria, Chee Cheng E
Department of Haematology-Oncology, National University Hospital Singapore, National University Cancer Institute, Singapore 119228, Singapore.
Cancers (Basel). 2020 Nov 26;12(12):3535. doi: 10.3390/cancers12123535.
The liver is the dominant site of metastasis for patients with colorectal cancer. For those with isolated liver metastases, surgical resection with systemic therapy has led to long-term remission in as high as 80% of patients in well-selected cohorts. This review will focus on how systemic therapy should be integrated with resection of liver metastases; in particular, the use of clinical risk scores based on clinicopathological features that help with patient selection, various approaches to the treatment of micro-metastatic disease (peri-operative versus post-operative chemotherapy), as well as conversion chemotherapy for those with initially upfront unresectable disease will be discussed.
肝脏是结直肠癌患者转移的主要部位。对于那些有孤立性肝转移的患者，手术切除联合全身治疗已使精心挑选的队列中高达80%的患者实现长期缓解。本综述将重点关注全身治疗应如何与肝转移灶切除相结合；特别是，将讨论基于临床病理特征的临床风险评分在患者选择中的应用、治疗微转移疾病的各种方法（围手术期化疗与术后化疗），以及对那些最初无法切除的疾病进行转化化疗的情况。
