Neurology, University of Tsukuba Hospital, Tsukuba, Ibaraki, Japan.
Neurology, University of Tsukuba Hospital, Tsukuba, Ibaraki, Japan
BMJ Case Rep. 2020 Nov 30;13(11):e237250. doi: 10.1136/bcr-2020-237250.
We provide the first report of amyopathic dermatomyositis combined with peripheral neuropathy. Our patient, a 49-year-old woman, initially experienced muscle weakness and tingling sensations in her legs, and nerve conduction study findings and the detection of antiganglioside antibodies indicated that she had autoimmune peripheral neuropathy. The unexpected presence of skin lesions, interstitial pneumonia and antibodies to melanoma differentiation-associated protein 5 prompted an additional diagnosis of amyopathic dermatomyositis. No previous report has described amyopathic dermatomyositis with peripheral neuropathy, and the present case provides evidence for the once-controversial concept of neuromyositis.
我们提供了首例无肌病性皮肌炎合并周围神经病的报告。我们的患者为一名 49 岁女性,最初出现腿部肌肉无力和刺痛感,神经传导研究结果和抗神经节苷脂抗体检测表明她患有自身免疫性周围神经病。意外出现的皮肤病变、间质性肺炎和黑色素瘤分化相关蛋白 5 抗体促使进一步诊断为无肌病性皮肌炎。之前没有报告描述过无肌病性皮肌炎伴周围神经病,本病例为一度存在争议的神经肌炎概念提供了证据。