Clark C R, Geffen G M, Geffen L B
Psychophysiology Laboratory, Flinders University of South Australia, Bedford Park.
Neurosci Biobehav Rev. 1987 Winter;11(4):353-64. doi: 10.1016/s0149-7634(87)80007-6.
Part I of this review [17] found evidence from animal and clinical studies of a role for catecholamines in the control of attention. This part of the review examines the results of a systematic study of the acute effects of a number of catecholamine active drugs on measures of attention in normal adults. The results are interpreted within the context of a general capacity model of information processing in which level of arousal determines the capacity to process stimulus information and level of activation the capacity for processing response demands. Whilst the dopamine antagonist, droperidol, and the alpha agonist, clonidine, had similar effects on behavioural indices of processing capacity and reports of the degree of effort required to carry out processing, they differentially affected subjective state and measures of activation and arousal. These differences provide some support for the hypothesis that central noradrenaline and dopamine modulate the capacity for early and late processing of information, respectively, in humans.
本综述的第一部分[17]从动物和临床研究中发现了儿茶酚胺在注意力控制中发挥作用的证据。本部分综述考察了一系列儿茶酚胺活性药物对正常成年人注意力指标的急性影响的系统研究结果。这些结果是在信息处理的一般能力模型背景下进行解释的，在该模型中，觉醒水平决定处理刺激信息的能力，激活水平决定处理反应需求的能力。虽然多巴胺拮抗剂氟哌利多和α激动剂可乐定对处理能力的行为指标以及执行处理所需努力程度的报告有相似影响，但它们对主观状态以及激活和觉醒指标有不同影响。这些差异为以下假设提供了一些支持：在人类中，中枢去甲肾上腺素和多巴胺分别调节信息早期和晚期处理的能力。
