Zhong Xin, Cao Zhongze, Song Jiayi, Liu Yuanmeng, Guo Qiang
Department of Pancreatic Surgery, West China Hospital, Sichuan University, Chengdu, Sichuan Province, China.
West China Medical School of Sichuan University, Chengdu, Sichuan Province, China.
Clin Appl Thromb Hemost. 2020 Jan-Dec;26:1076029620977906. doi: 10.1177/1076029620977906.
The biomarkers for predicting venous thromboembolic events (VTEs) after oncologic surgery are still lacking. The current study aimed to analyze the relationships of CD62P and GP IIb/IIIa with hypercoagulation after oncologic surgery. A total of 76 patients with primary abdominopelvic tumors in our hospital were enrolled. The patients were divided into groups A (malignancy with no VTE group), B (malignancy with VTE group), and C (benign with no VTE group). Twenty healthy volunteers were selected as control. The plasma CD62P (4.69 ± 2.55 vs. 1.76 ± 0.48) and the GP IIb/IIIa (9.28 ± 3.79 vs. 1.76 ± 0.48) levels in group A were significantly higher than those in the control group preoperatively. The CD62P (31.46 ± 17.13 vs. 13.51 ± 7.43, < 0.05), GP IIb/IIIa (42.33 ± 21.82 vs. 13.51 ± 7.43, < 0.05), and D-dimer (7.33 ± 2.34 vs. 2.03 ± 0.55, < 0.05) levels in group B were markedly higher 7 days after operation compared with those in group A. The CD62P and the GP IIb/IIIa exhibited a positive correlation with the hypercoagulable state after oncologic surgery.
目前仍缺乏预测肿瘤手术后静脉血栓栓塞事件(VTEs)的生物标志物。本研究旨在分析CD62P和糖蛋白IIb/IIIa(GP IIb/IIIa)与肿瘤手术后高凝状态的关系。我院共纳入76例原发性腹盆腔肿瘤患者。将患者分为A组(恶性肿瘤无VTE组)、B组(恶性肿瘤有VTE组)和C组(良性肿瘤无VTE组)。选取20名健康志愿者作为对照。术前A组血浆CD62P水平(4.69±2.55 vs. 1.76±0.48)和GP IIb/IIIa水平(9.28±3.79 vs. 1.76±0.48)显著高于对照组。术后7天,B组的CD62P水平(31.46±17.13 vs. 13.51±7.43,P<0.05)、GP IIb/IIIa水平(42.33±21.82 vs. 13.51±7.43,P<0.05)和D-二聚体水平(7.33±2.34 vs. 2.03±0.55,P<0.05)均明显高于A组。CD62P和GP IIb/IIIa与肿瘤手术后的高凝状态呈正相关。