Department of Pathophysiology, Third Military Medical University, Chongqing 400038, China.
Department of Microbiology and Immunology, Shanxi Medical University, Taiyuan 030001, China.
Int J Med Sci. 2019 Jan 1;16(2):292-301. doi: 10.7150/ijms.28047. eCollection 2019.
Circular (circ)RNAs, a newly recognized class of noncoding RNA, have been implicated in the occurrence and development of several diseases, including neurological and cardiovascular diseases. Studies of human tumors, including those of liver cancer, gastric cancer, lung cancer and colorectal cancer, have shown differential expression profiles of circRNAs, suggesting regulatory roles in cancer pathogenesis and metastasis. In this review, we discuss the most recent research into tumor-related circRNAs, providing a comprehensive summary of the expression or/and function of these circRNAs and proposing rational perspectives on the potential clinical application of circRNAs as helpful biomarkers or therapeutic targets in human tumors.
环状 RNA（circRNAs）是一类新发现的非编码 RNA，已被证实与多种疾病（包括神经和心血管疾病）的发生和发展有关。对人类肿瘤的研究，包括肝癌、胃癌、肺癌和结直肠癌，表明 circRNAs 的表达谱存在差异，提示其在肿瘤发生和转移中起调控作用。在这篇综述中，我们讨论了与肿瘤相关的 circRNAs 的最新研究进展，全面总结了这些 circRNAs 的表达和/或功能，并对 circRNAs 作为人类肿瘤有帮助的生物标志物或治疗靶点的潜在临床应用提出了合理的观点。
