• 文献检索
  • 文档翻译
  • 深度研究
  • 学术资讯
  • Suppr Zotero 插件Zotero 插件
  • 邀请有礼
  • 套餐&价格
  • 历史记录
应用&插件
Suppr Zotero 插件Zotero 插件浏览器插件Mac 客户端Windows 客户端微信小程序
定价
高级版会员购买积分包购买API积分包
服务
文献检索文档翻译深度研究API 文档MCP 服务
关于我们
关于 Suppr公司介绍联系我们用户协议隐私条款
关注我们

Suppr 超能文献

核心技术专利：CN118964589B侵权必究
粤ICP备2023148730 号-1Suppr @ 2026

文献检索

告别复杂PubMed语法，用中文像聊天一样搜索，搜遍4000万医学文献。AI智能推荐，让科研检索更轻松。

立即免费搜索

文件翻译

保留排版，准确专业，支持PDF/Word/PPT等文件格式，支持 12+语言互译。

免费翻译文档

深度研究

AI帮你快速写综述，25分钟生成高质量综述，智能提取关键信息，辅助科研写作。

立即免费体验

透明质酸膀胱内灌注与膀胱逼尿肌内注射A型肉毒杆菌毒素或膀胱镜水扩张治疗氯胺酮相关性膀胱炎的比较。

Comparison of intravesical instillation of hyaluronic acid with intradetrusor botulinum toxin A injection or cystoscopic hydrodistention for ketamine-associated cystitis.

作者信息

Li Bingkun, Leng Qu, Li Chuanyin, Tan Xiao, Su Wei, Li Chaoming

机构信息

Department of Urology, Zhujiang Hospital, Southern Medical University, Guangzhou, Guangdong, China.

Department of Urology, Zhongshan City People's Hospital, Zhongshan, Guangdong, China.

出版信息

J Int Med Res. 2020 Nov;48(11):300060520973100. doi: 10.1177/0300060520973100.

DOI:10.1177/0300060520973100
PMID:33259240
原文链接:https://pmc.ncbi.nlm.nih.gov/articles/PMC7711230/
Abstract

OBJECTIVE

This study aimed to compare the therapeutic effect of intravesical instillation hyaluronic acid with intradetrusor botulinum toxin A (BTX-A) injection or cystoscopic hydrodistention for ketamine-associated cystitis.

METHODS

Thirty-six patients were evenly randomly divided into the BTX-A group or the hydrodistention group. Patients received 200 U BTX-A detrusor injections in the BTX-A group and cystoscopic hydrodistention in the hydrodistention group. Intravesical instillation of hyaluronic acid was administrated in both groups for eight times. Patients with involuntary detrusor contraction were divided into the persistent involuntary detrusor contraction group and resolved involuntary detrusor contraction group after treatment in 6 months. The predictors of persistent involuntary detrusor contraction were analyzed.

RESULTS

Twelve months after treatment, the daytime frequency, Interstitial Cystitis Symptom Index, maximal capacity, and maximal cystometric capacity in the BTX-A group were significantly better than those in the hydrodistention group. Patients with resolution of involuntary detrusor contraction had a significantly shorter duration of ketamine, lower amount of fibrosis in pathology, and higher maximal capacity than those with persistent involuntary detrusor contraction 6 months after therapy.

CONCLUSION

Intravesical instillation of hyaluronic acid with intradetrusor BTX-A injection appears to be a preferable option for long-term effectiveness compared with cystoscopic hydrodistention.

摘要

目的

本研究旨在比较膀胱内灌注透明质酸与膀胱逼尿肌内注射A型肉毒杆菌毒素（BTX-A）或膀胱镜水扩张术治疗氯胺酮相关性膀胱炎的疗效。

方法

36例患者被均匀随机分为BTX-A组或水扩张组。BTX-A组患者接受200 U BTX-A逼尿肌注射，水扩张组患者接受膀胱镜水扩张术。两组均进行8次膀胱内透明质酸灌注。将治疗6个月后出现逼尿肌不自主收缩的患者分为持续性逼尿肌不自主收缩组和缓解性逼尿肌不自主收缩组。分析持续性逼尿肌不自主收缩的预测因素。

结果

治疗12个月后，BTX-A组的日间排尿频率、间质性膀胱炎症状指数、最大容量和最大膀胱测压容量均显著优于水扩张组。与治疗6个月后持续性逼尿肌不自主收缩的患者相比，逼尿肌不自主收缩缓解的患者氯胺酮使用时间显著缩短，病理纤维化程度更低，最大容量更高。

结论

与膀胱镜水扩张术相比，膀胱内灌注透明质酸联合膀胱逼尿肌内注射BTX-A似乎是一种长期疗效更佳的选择。

https://cdn.ncbi.nlm.nih.gov/pmc/blobs/380a/7711230/753abb594e35/10.1177_0300060520973100-fig5.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/380a/7711230/54e6fcd28401/10.1177_0300060520973100-fig1.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/380a/7711230/e36fc2f81854/10.1177_0300060520973100-fig2.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/380a/7711230/e73845f20b45/10.1177_0300060520973100-fig3.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/380a/7711230/e38d0bcd4542/10.1177_0300060520973100-fig4.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/380a/7711230/753abb594e35/10.1177_0300060520973100-fig5.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/380a/7711230/54e6fcd28401/10.1177_0300060520973100-fig1.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/380a/7711230/e36fc2f81854/10.1177_0300060520973100-fig2.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/380a/7711230/e73845f20b45/10.1177_0300060520973100-fig3.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/380a/7711230/e38d0bcd4542/10.1177_0300060520973100-fig4.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/380a/7711230/753abb594e35/10.1177_0300060520973100-fig5.jpg

相似文献

1
Comparison of intravesical instillation of hyaluronic acid with intradetrusor botulinum toxin A injection or cystoscopic hydrodistention for ketamine-associated cystitis.透明质酸膀胱内灌注与膀胱逼尿肌内注射A型肉毒杆菌毒素或膀胱镜水扩张治疗氯胺酮相关性膀胱炎的比较。
J Int Med Res. 2020 Nov;48(11):300060520973100. doi: 10.1177/0300060520973100.
2
Intravesical injection of botulinum toxin A for treatment of interstitial cystitis/bladder pain syndrome: 10 years of experience at a single center in China.膀胱内注射A型肉毒杆菌毒素治疗间质性膀胱炎/膀胱疼痛综合征：中国一家单中心的10年经验
Int Urogynecol J. 2015 Jul;26(7):1021-6. doi: 10.1007/s00192-015-2631-y. Epub 2015 Feb 18.
3
Early experimental results of using a novel delivery carrier, hyaluronan-phosphatidylethanolamine (HA-PE), which may allow simple bladder instillation of botulinum toxin A as effectively as direct detrusor muscle injection.新型递送载体透明质酸-磷脂酰乙醇胺（HA-PE）的早期实验结果可能使肉毒毒素 A 的膀胱内灌注与直接逼尿肌注射一样有效。
J Pediatr Urol. 2018 Apr;14(2):172.e1-172.e6. doi: 10.1016/j.jpurol.2017.11.016. Epub 2017 Dec 30.
4
An indirect comparison meta-analysis of noninvasive intravesical instillation and intravesical injection of botulinum toxin-A in bladder disorders.经尿道膀胱内灌注和注射肉毒毒素 A 治疗膀胱疾病的间接比较的荟萃分析。
Int Urol Nephrol. 2022 Mar;54(3):479-491. doi: 10.1007/s11255-022-03107-6. Epub 2022 Jan 19.
5
Intravesical instillation of hyaluronic acid prolonged the effect of bladder hydrodistention in patients with severe interstitial cystitis.膀胱内注射透明质酸可延长严重间质性膀胱炎患者膀胱水扩张的疗效。
Urology. 2010 Mar;75(3):547-50. doi: 10.1016/j.urology.2009.09.078.
6
Intravesical botulinum toxin type A in chronic interstitial cystitis: results of a pilot study.
Surgeon. 2007 Dec;5(6):331-3. doi: 10.1016/s1479-666x(07)80084-9.
7
Comparison of intravesical botulinum toxin type A injections plus hydrodistention with hydrodistention alone for the treatment of refractory interstitial cystitis/painful bladder syndrome.膀胱内注射A型肉毒杆菌毒素联合膀胱水扩张与单纯膀胱水扩张治疗难治性间质性膀胱炎/疼痛性膀胱综合征的比较。
BJU Int. 2009 Sep;104(5):657-61. doi: 10.1111/j.1464-410X.2009.08495.x. Epub 2009 Mar 30.
8
Comparison of the Clinical Efficacy and Adverse Events between Intravesical Injections of Platelet-Rich Plasma and Botulinum Toxin A for the Treatment of Interstitial Cystitis Refractory to Conventional Treatment.富血小板血浆与肉毒毒素 A 膀胱内注射治疗常规治疗抵抗性间质性膀胱炎的临床疗效和不良反应比较。
Toxins (Basel). 2023 Feb 2;15(2):121. doi: 10.3390/toxins15020121.
9
Evaluation of pain and quality of life after hyaluronic acid instillation in addition to botulinum toxin-A injection in women with refractory Interstitial Cystitis/Painful Bladder Syndrome: A pilot study.评估在难治性间质性膀胱炎/膀胱疼痛综合征女性中，在注射肉毒毒素 A 的基础上联合透明质酸灌注治疗后的疼痛和生活质量：一项初步研究。
Arch Ital Urol Androl. 2022 Dec 27;94(4):447-450. doi: 10.4081/aiua.2022.4.447.
10
Single-institution experience in 110 patients with botulinum toxin A injection into bladder or urethra.110例患者膀胱或尿道注射A型肉毒杆菌毒素的单机构经验。
Urology. 2005 Jan;65(1):37-41. doi: 10.1016/j.urology.2004.08.016.

引用本文的文献

1
Evaluation of clinical efficacy of pelvic ultrasound monitoring combined with scale scoring in the treatment of interstitial cystitis by intravesical instillation regimen combined with hydrodistention and transurethral fulguration.盆腔超声监测联合量表评分在膀胱水扩张联合经尿道电灼术膀胱灌注方案治疗间质性膀胱炎中的临床疗效评估
BMC Urol. 2025 May 7;25(1):117. doi: 10.1186/s12894-025-01764-0.
2
[Treatment of intravesical instillation with fulguration-hydrodistention on female interstitial cystitis].[电灼-膀胱扩张术膀胱内灌注治疗女性间质性膀胱炎]
Beijing Da Xue Xue Bao Yi Xue Ban. 2023 Oct 18;55(5):865-870. doi: 10.19723/j.issn.1671-167X.2023.05.014.
3

本文引用的文献

1
Complete reversal of the clinical symptoms and image morphology of ketamine cystitis after intravesical hyaluronic acid instillation: A case report.膀胱内注射透明质酸后氯胺酮膀胱炎临床症状及影像形态完全逆转：一例报告
Medicine (Baltimore). 2018 Jul;97(28):e11500. doi: 10.1097/MD.0000000000011500.
2
Electron microscopic characteristics of interstitial cystitis/bladder pain syndrome and their association with clinical condition.间质性膀胱炎/膀胱疼痛综合征的电子显微镜特征及其与临床状况的关系。
PLoS One. 2018 Jun 7;13(6):e0198816. doi: 10.1371/journal.pone.0198816. eCollection 2018.
3
Intratrigonal OnabotulinumtoxinA Improves Bladder Symptoms and Quality of Life in Patients with Bladder Pain Syndrome/Interstitial Cystitis: A Pilot, Single Center, Randomized, Double-Blind, Placebo Controlled Trial.
Pathophysiology, clinical presentation, and management of ketamine-induced cystitis.
氯胺酮所致膀胱炎的病理生理学、临床表现及管理
Tzu Chi Med J. 2023 Jun 13;35(3):205-212. doi: 10.4103/tcmj.tcmj_94_23. eCollection 2023 Jul-Sep.
4
Diagnostic and therapeutic cystoscopy in bladder pain syndrome/interstitial cystitis: systematic review of literature and consensus on methodology.膀胱疼痛综合征/间质性膀胱炎的诊断和治疗性膀胱镜检查：文献系统评价和方法学共识。
Int Urogynecol J. 2023 Jun;34(6):1165-1173. doi: 10.1007/s00192-023-05449-w. Epub 2023 Jan 28.
三角区注射肉毒毒素 A 改善膀胱疼痛综合征/间质性膀胱炎患者的膀胱症状和生活质量：一项单中心、随机、双盲、安慰剂对照的初步研究。
J Urol. 2018 Apr;199(4):998-1003. doi: 10.1016/j.juro.2017.10.018. Epub 2017 Oct 13.
4
Intravesical Botulinum Toxin A Injections for Bladder Pain Syndrome/Interstitial Cystitis: A Systematic Review and Meta-Analysis of Controlled Studies.膀胱内注射A型肉毒杆菌毒素治疗膀胱疼痛综合征/间质性膀胱炎：对照研究的系统评价和荟萃分析
Med Sci Monit. 2016 Sep 14;22:3257-67. doi: 10.12659/msm.897350.
5
Hydrodistension plus Onabotulinumtoxin A in bladder pain syndrome refractory to conservative treatments.
Actas Urol Esp. 2016 Jun;40(5):303-8. doi: 10.1016/j.acuro.2015.12.011. Epub 2016 Feb 11.
6
Role of Bladder Hydrodistention and Intravesical Sodium Hyaluronate in the Treatment of Interstitial Cystitis.膀胱水扩张及膀胱内注射透明质酸钠在间质性膀胱炎治疗中的作用
Urol J. 2015 Dec 23;12(6):2417-21.
7
Is Urodynamic Study a Good Witness to the Progression of Ketamine-Associated Cystitis?
Low Urin Tract Symptoms. 2014 May;6(2):98-102. doi: 10.1111/luts.12029. Epub 2013 Sep 5.
8
Long-Term Efficacy and Safety of Repeated Intravescial OnabotulinumtoxinA Injections Plus Hydrodistention in the Treatment of Interstitial Cystitis/Bladder Pain Syndrome.重复膀胱内注射A型肉毒杆菌毒素联合膀胱水扩张术治疗间质性膀胱炎/膀胱疼痛综合征的长期疗效和安全性
Toxins (Basel). 2015 Oct 22;7(10):4283-93. doi: 10.3390/toxins7104283.
9
Treatment of bladder pain syndrome and interstitial cystitis: a systematic review.膀胱疼痛综合征与间质性膀胱炎的治疗：一项系统评价
Int Urogynecol J. 2016 May;27(5):697-708. doi: 10.1007/s00192-015-2815-5. Epub 2015 Aug 14.
10
O'Leary-Sant Symptom Index Predicts the Treatment Outcome for OnabotulinumtoxinA Injections for Refractory Interstitial Cystitis/Bladder Pain Syndrome.奥利里 - 桑特症状指数可预测肉毒杆菌毒素A注射治疗难治性间质性膀胱炎/膀胱疼痛综合征的疗效。
Toxins (Basel). 2015 Jul 30;7(8):2860-71. doi: 10.3390/toxins7082860.