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在撒哈拉以南非洲地区,减少重度间歇性饮酒的干预措施的系统评价。

A systematic review of interventions for reducing heavy episodic drinking in sub-Saharan African settings.

机构信息

Department of Public Health, University of Texas at San Antonio, San Antonio, Texas, United States of America.

Division of Epidemiology and Biostatistics, San Diego State University School of Public Health, San Diego, California, United States of America.

出版信息

PLoS One. 2020 Dec 1;15(12):e0242678. doi: 10.1371/journal.pone.0242678. eCollection 2020.

Abstract

OBJECTIVE

Assess the effect of non-pharmacological alcohol interventions on reducing heavy episodic drinking (HED) outcomes in sub-Saharan Africa.

METHODS

A systematic review of the available literature through August 19, 2020 was conducted. Randomized and non-randomized controlled trials testing non-pharmacological interventions on alcohol consumption in sub-Saharan Africa were eligible for inclusion. Eligible outcomes included measures of HED/binge drinking, and measures indicative of this pattern of drinking, such as high blood alcohol concentration or frequency of intoxication. Three authors extracted and reconciled relevant data and assessed risk of bias. The review protocol is available on PROSPERO (registration number: CRD42019094509). The Cochrane Handbook recommendations for the review of interventions and the Preferred Reporting Items for Systematic Reviews and Meta-Analyses (PRISMA) guidelines guided all methodology.

RESULTS

Thirteen intervention trials were identified that met our inclusion criteria and measured change in HED. Studies were judged of moderate quality. A beneficial effect of non-pharmacological interventions on HED was reported in six studies, three of which were deemed clinically significant by the review authors; no statistically significant effects were identified in the other seven studies. Interventions achieving statistical and/or clinical significance had an intervention dose of two hours or greater, used an array of psychosocial approaches, including Motivational Interviewing integrated in Brief Intervention, cognitive behavioral therapy and integrated risk reduction interventions, and were delivered both individually and in groups.

CONCLUSIONS

Evidence for the effectiveness of non-pharmacological interventions to reduce HED in sub-Saharan African settings was limited, demonstrating the need for more research. To strengthen the literature, future research should employ more rigorous study designs, improve consistency of HED measurement, test interventions developed specifically to address HED, and explore structural approaches to HED reduction.

摘要

目的

评估非药物性酒精干预措施对减少撒哈拉以南非洲地区重度饮酒(HED)结局的效果。

方法

对截至 2020 年 8 月 19 日的现有文献进行系统评价。纳入了在撒哈拉以南非洲地区测试非药物干预措施对酒精消耗影响的随机和非随机对照试验。合格的结局包括 HED/狂饮的测量,以及指示这种饮酒模式的测量,如血液酒精浓度或醉酒频率。三位作者提取并调和了相关数据,并评估了偏倚风险。该综述方案可在 PROSPERO(注册号:CRD42019094509)上查阅。干预措施审查的 Cochrane 手册建议和系统评价和荟萃分析的首选报告项目(PRISMA)指南指导了所有方法。

结果

确定了 13 项符合纳入标准并测量 HED 变化的干预试验。研究被评为中等质量。六项研究报告了非药物干预对 HED 的有益影响,其中三项被综述作者认为具有临床意义;其他七项研究未发现统计学显著影响。达到统计学和/或临床意义的干预措施的干预剂量为两小时或更长时间,采用了一系列心理社会方法,包括纳入简短干预的动机性访谈、认知行为疗法和综合风险降低干预措施,并且是个体和小组形式提供的。

结论

在撒哈拉以南非洲地区,非药物干预措施减少 HED 的有效性证据有限,表明需要更多的研究。为了加强文献,未来的研究应采用更严格的研究设计,提高 HED 测量的一致性,测试专门针对 HED 开发的干预措施,并探索减少 HED 的结构性方法。

https://cdn.ncbi.nlm.nih.gov/pmc/blobs/6bb9/7707537/2a1f20bc0886/pone.0242678.g001.jpg

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