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放疗和雄激素剥夺疗法治疗前列腺癌所致性功能障碍的管理:根据疾病阶段比较泌尿肿瘤学实践。

The management of sexual dysfunction resulting from radiotherapy and androgen deprivation therapy to treat prostate cancer: A comparison of uro-oncology practice according to disease stage.

机构信息

University College London Hospitals NHS Foundation Trust, London, United Kingdom.

Trends in Urology &, Men's Health, London, United Kingdom.

出版信息

Int J Clin Pract. 2021 Apr;75(4):e13873. doi: 10.1111/ijcp.13873. Epub 2020 Dec 28.

DOI:10.1111/ijcp.13873
PMID:33260255
Abstract

OBJECTIVES

To establish current uro-oncology practice in the management of sexual dysfunction (SD) following radiotherapy (RT) and/or androgen deprivation therapy (ADT) to treat prostate cancer. To identify differences in approach to the management of SD according to disease stage.

SUBJECTS AND METHODS

A 14-question mixed methods survey was designed to assess the current UK practice. Closed- and open-ended questions were used to quantify results while allowing participants to expand on answers. The survey was distributed to members of the British Uro-Oncology Group at the 2019 annual meeting.

RESULTS

Surveys were completed by 63 uro-oncologists attending the annual meeting of the British Uro-Oncology Group (response rate 66%). The major issue highlighted was a difference in approach to managing SD according to disease stage. More than half of the participants (56%) said 'advanced stage of disease' was a barrier to discussing SD. Clinicians were less likely to discuss SD, take baseline assessments, refer to a specialist clinic or offer rehabilitation when dealing with patients with advanced disease. Only a minority said that the management of SD was primarily their responsibility (11%). Nearly all clinicians (92%) had access to SD clinics; however, the majority of clinicians did not routinely refer patients.

CONCLUSIONS

This study shows that men with advanced prostate cancer need better support in managing SD. Patients receiving long-term ADT are less likely to be offered any kind of help or intervention. Specific guidance on managing SD in this cohort may result in improvements in sexual function, emotional well-being, quality of life, mental health and confidence.

摘要

目的

确定英国目前在治疗前列腺癌时,对放疗(RT)和/或雄激素剥夺疗法(ADT)后性功能障碍(SD)的管理方法。根据疾病分期,确定在 SD 管理方法上的差异。

受试者和方法

设计了一个包含 14 个问题的混合方法调查,以评估英国目前的实践情况。使用封闭式和开放式问题来量化结果,同时允许参与者扩展答案。该调查分发给了 2019 年英国泌尿肿瘤学组年会上的成员。

结果

共有 63 名参加英国泌尿肿瘤学组年会的泌尿肿瘤学家完成了调查(回应率为 66%)。突出的主要问题是根据疾病分期,SD 的管理方法存在差异。超过一半的参与者(56%)表示“疾病晚期”是讨论 SD 的障碍。当处理晚期疾病患者时,临床医生不太可能讨论 SD,进行基线评估,转介到专科诊所或提供康复治疗。只有少数人表示(11%)SD 的管理主要是他们的责任。几乎所有的临床医生(92%)都可以访问 SD 诊所;然而,大多数临床医生没有定期转介患者。

结论

这项研究表明,晚期前列腺癌患者需要更好的 SD 管理支持。接受长期 ADT 的患者不太可能获得任何形式的帮助或干预。在这一队列中,对 SD 管理的具体指导可能会改善性功能、情绪健康、生活质量、心理健康和信心。

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