School of Biomedical Sciences, Li Ka Shing Faculty of Medicine, The University of Hong Kong, Hong Kong.
Department of Medicine, Li Ka Shing Faculty of Medicine, The University of Hong Kong, Queen Mary Hospital, Hong Kong.
Psychogeriatrics. 2021 Jan;21(1):100-111. doi: 10.1111/psyg.12636. Epub 2020 Dec 1.
Mild behavioural impairment (MBI) is a neurobehavioural syndrome characterized by emergent neuropsychiatric symptoms in later life. There has been no systematic review or meta-analysis on the prevalence of MBI. The main aim of the study is to calculate the pooled prevalence of MBI.
A search of the literature on MBI in mild cognitive impairment (MCI), cognitively normal (CN), and subjective cognitive impairment (SCI) and CN but at risk (CN-AR) subjects published between 1 January 2003 and 28 September 2020 was conducted. Meta-analysis using a random effects model was performed to determine the pooled estimate of the prevalence of MBI. Meta-regression was performed to identify factors contributing to the variance of prevalence rate. A systematic review was also performed to study the impact of MBI in cognitive outcomes and its correlation to the pathology and genetics of Alzheimer's disease.
Eleven studies conducted among 15 689 subjects underwent meta-analysis, revealing the pooled prevalence of MBI to be 33.5% (95% confidence interval (CI): 22.6%-46.6%). Seven studies conducted among 1358 MCI subjects underwent meta-analysis, revealing the pooled prevalence to be 45.5% (95%CI: 36.1%-55.3%). Four studies conducted among 13 153 CN subjects underwent meta-analysis, revealing the pooled prevalence to be 17.0% (95%CI: 7.2%-34.9%). Five studies conducted among 1158 SCI or CN-AR subjects underwent meta-analysis, revealing the pooled prevalence to be 35.8% (95%CI: 21.4%-53.2%). A systematic review of 13 studies showed that MBI has a significant impact on cognitive deterioration and is associated with the pathology and genetics of Alzheimer's disease.
In MCI, CN, and SCI and CN-AR subjects, MBI is common. Our finding is potentially useful in planning future clinical trials.
轻度行为障碍（MBI）是一种神经行为综合征，其特征是晚年出现神经精神症状。目前还没有关于 MBI 患病率的系统评价或荟萃分析。本研究的主要目的是计算 MBI 的总患病率。
对 2003 年 1 月 1 日至 2020 年 9 月 28 日期间发表的轻度认知障碍（MCI）、认知正常（CN）和主观认知障碍（SCI）以及认知正常但有风险（CN-AR）患者的 MBI 文献进行检索。采用随机效应模型进行荟萃分析，以确定 MBI 患病率的总估计值。进行荟萃回归分析以确定导致患病率差异的因素。还进行了系统评价，以研究 MBI 对认知结局的影响及其与阿尔茨海默病的病理学和遗传学的相关性。
对 15689 名受试者进行的 11 项研究进行了荟萃分析，结果显示 MBI 的总患病率为 33.5%（95%置信区间[CI]：22.6%-46.6%）。对 1358 名 MCI 受试者进行的 7 项研究进行了荟萃分析，结果显示 MBI 的总患病率为 45.5%（95%CI：36.1%-55.3%）。对 13153 名 CN 受试者进行的 4 项研究进行了荟萃分析，结果显示 MBI 的总患病率为 17.0%（95%CI：7.2%-34.9%）。对 1158 名 SCI 或 CN-AR 受试者进行的 5 项研究进行了荟萃分析，结果显示 MBI 的总患病率为 35.8%（95%CI：21.4%-53.2%）。对 13 项研究的系统评价显示，MBI 对认知恶化有显著影响，并与阿尔茨海默病的病理学和遗传学有关。
在 MCI、CN 和 SCI 以及 CN-AR 患者中，MBI 很常见。我们的发现可能有助于计划未来的临床试验。
