Souêtre E, Salvati E, Darcourt G
Clinique de psychiatrie et de psychologie médicale, Hôpital Pasteur, Nice, France.
Rev Electroencephalogr Neurophysiol Clin. 1987 Dec;17(4):359-76. doi: 10.1016/s0370-4475(87)80083-7.
The chronobiological hypotheses of depression are based on epidemiological, biological as well as therapeutical pieces of evidence. The seasonal pattern of depression and suicide rates tend to link affective disorders and the daylight duration. Disturbances of circadian rhythms have been reported in endogenous depression. Treatments of depression, such as manipulations of the sleep/wake cycle, phototherapy or tricyclics, may involve chronobiological mechanisms on endogenous pacemakers. Beside the phase advance hypothesis of depression, present data seem to involve a disturbance of the mechanisms of entrainment of the internal clocks by external synchronizers. Other psychiatric illnesses may thus be linked to chronobiological abnormalities.
抑郁症的生物钟学假说是基于流行病学、生物学以及治疗学方面的证据。抑郁症和自杀率的季节性模式往往将情感障碍与日照时长联系起来。内源性抑郁症患者存在昼夜节律紊乱的情况。抑郁症的治疗方法，如对睡眠/清醒周期的调控、光疗法或三环类药物治疗，可能涉及对内源性起搏器的生物钟学机制。除了抑郁症的相位提前假说外，目前的数据似乎还涉及外部同步器对内部时钟的同步机制的干扰。因此，其他精神疾病可能与生物钟学异常有关。
