TriHealth Bethesda Butler Hospital, Hamilton, OH.
Seven Hills Anesthesia, Cincinnati, OH.
J Perianesth Nurs. 2021 Apr;36(2):162-166. doi: 10.1016/j.jopan.2020.07.010. Epub 2020 Nov 28.
Preoperative acetaminophen is recognized as an effective part of the multimodal approach to perioperative pain management. The present study, conducted between April 12, 2018 and February 14, 2019, examined whether there are differences in patient-reported pain, postoperative opioid consumption, negative opioid effects, length of postanesthesia care unit stay, and patient satisfaction with pain control between patients who receive intravenous (IV) acetaminophen and patients who receive oral acetaminophen.
This double-blinded, randomized controlled trial was conducted among 120 patients undergoing outpatient surgery.
Patients were randomized to receive preoperatively either intravenous (IV) acetaminophen (and oral placebo) or oral acetaminophen (and IV placebo). Results were analyzed using SPSS statistical software; statistical analyses consisted of Mann-Whitney U test, independent samples t test, and χ test. In all analyses, a P value less than .05 was considered significant.
There were no significant differences in any outcome measures based on the route of acetaminophen administration.
The findings of the present study support the practice of administering oral acetaminophen, as opposed to IV acetaminophen, preoperatively as part of the multimodal approach to manage postoperative pain in patients able to tolerate preoperative oral medications.
术前应用对乙酰氨基酚已被公认为围手术期疼痛管理多模式方法的有效组成部分。本研究于 2018 年 4 月 12 日至 2019 年 2 月 14 日进行，旨在探讨接受静脉（IV）对乙酰氨基酚和口服对乙酰氨基酚的患者在患者报告的疼痛、术后阿片类药物消耗、阿片类药物的负面效应、麻醉后护理单元停留时间和对疼痛控制的满意度方面是否存在差异。
这是一项双盲、随机对照试验，在 120 例接受门诊手术的患者中进行。
患者被随机分为术前接受静脉（IV）对乙酰氨基酚（和口服安慰剂）或口服对乙酰氨基酚（和 IV 安慰剂）。使用 SPSS 统计软件分析结果；统计分析包括 Mann-Whitney U 检验、独立样本 t 检验和 χ 检验。在所有分析中，P 值小于 0.05 被认为具有统计学意义。
基于对乙酰氨基酚给药途径，任何结果测量均无显著差异。
本研究的结果支持在能够耐受术前口服药物的患者中，作为多模式方法的一部分，术前给予口服对乙酰氨基酚而不是 IV 对乙酰氨基酚来管理术后疼痛的做法。
