硫酸盐和葡糖醛酸共轭物的化学合成方法综述。
A review of the methods of chemical synthesis of sulphate and glucuronide conjugates.
作者信息
Kaspersen F M, Van Boeckel C A
机构信息
Organon Scientific Development Group, Oss, The Netherlands.
出版信息
Xenobiotica. 1987 Dec;17(12):1451-71. doi: 10.3109/00498258709044005.
PMID:3326299
Abstract
- Methods for the synthesis of drug conjugates with sulphuric acid have been reviewed. 2. Some analytical methods are presented for the analysis of sulphate conjugates. 3. The synthesis of several types of N, O and C beta-D-glucuronides is reviewed. Different beta-coupling reactions of protected glucuronides are presented. 4. Application of n.m.r. and mass spectrometry to the analysis of beta-D-glucuronides is discussed.
摘要
- 综述了用硫酸合成药物缀合物的方法。2. 介绍了一些用于分析硫酸酯缀合物的分析方法。3. 综述了几种类型的N、O和Cβ-D-葡萄糖醛酸苷的合成。介绍了保护型葡萄糖醛酸苷的不同β-偶联反应。4. 讨论了核磁共振和质谱在β-D-葡萄糖醛酸苷分析中的应用。
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