氧化应激和组织 HSP70 减少与脓毒症的发生有关：HSP70 作为治疗靶点。
Oxidative stress and decreased tissue HSP70 are involved in the genesis of sepsis: HSP70 as a therapeutic target.
机构信息
Grupo de Pesquisa em Fisiologia, Departamento de Ciências da Vida, Universidade Regional do Noroeste do Estado do Rio Grande do Sul - Ijuí (RS), Brasil.
Programa de Pós-Graduação em Atenção Integral à Saúde, Departamento de Ciências da Vida, Universidade Regional do Noroeste do Estado do Rio Grande do Sul - Ijuí (RS), Brasil.
出版信息
Rev Bras Ter Intensiva. 2020 Oct-Dec;32(4):585-591. doi: 10.5935/0103-507X.20200084.
Abstract
Sepsis is a systemic infection that causes multiple organ dysfunction. HSP70 is a protein responsive to cell stress, in particular oxidative stress. Therefore, this literature review sought to investigate the roles of HSP70 and oxidative stress in the pathophysiology of sepsis and the possibility of HSP70 as a therapeutic target. HSP70 exerts a protective effect when located in cells (iHSP70), and its decrease, as well as its increase in the extracellular environment (eHSP70), under oxidative stress is a biomarker of sepsis severity. In addition, therapies that increase iHSP70 and treatment with HSP70 promote sepsis improvement.
摘要
败血症是一种全身性感染，可导致多器官功能障碍。HSP70 是一种对细胞应激（尤其是氧化应激）有反应的蛋白质。因此，本文献综述旨在探讨 HSP70 和氧化应激在败血症病理生理学中的作用，以及 HSP70 作为治疗靶点的可能性。HSP70 在细胞内（iHSP70）时发挥保护作用，而在氧化应激下其在细胞外环境中的减少（eHSP70）及其增加是败血症严重程度的生物标志物。此外，增加 iHSP70 的治疗方法和 HSP70 的治疗均促进败血症的改善。
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2
Impact of Body Temperature Abnormalities on the Implementation of Sepsis Bundles and Outcomes in Patients With Severe Sepsis: A Retrospective Sub-Analysis of the Focused Outcome Research on Emergency Care for Acute Respiratory Distress Syndrome, Sepsis and Trauma Study.
Crit Care Med. 2019 May;47(5):691-699. doi: 10.1097/CCM.0000000000003688.
3
Cerebral Autoregulation-Guided Optimal Blood Pressure in Sepsis-Associated Encephalopathy: A Case Series.
J Intensive Care Med. 2020 Dec;35(12):1453-1464. doi: 10.1177/0885066619828293. Epub 2019 Feb 13.
4
Probenecid Relieves Cerebral Dysfunction of Sepsis by Inhibiting Pannexin 1-Dependent ATP Release.
Inflammation. 2019 Jun;42(3):1082-1092. doi: 10.1007/s10753-019-00969-4.
5
Protective Effect of Hesperidin Against Sepsis-Induced Lung Injury by Inducing the Heat-Stable Protein 70 (Hsp70)/Toll-Like Receptor 4 (TLR4)/ Myeloid Differentiation Primary Response 88 (MyD88) Pathway.
Med Sci Monit. 2019 Jan 4;25:107-114. doi: 10.12659/MSM.912490.
6
Hsp70 Suppresses Mitochondrial Reactive Oxygen Species and Preserves Pulmonary Microvascular Barrier Integrity Following Exposure to Bacterial Toxins.
Front Immunol. 2018 Jun 12;9:1309. doi: 10.3389/fimmu.2018.01309. eCollection 2018.
7
Receptor for advanced glycation end products mediates sepsis-triggered amyloid-β accumulation, Tau phosphorylation, and cognitive impairment.
J Biol Chem. 2018 Jan 5;293(1):226-244. doi: 10.1074/jbc.M117.786756. Epub 2017 Nov 10.
8
The critical role played by endotoxin-induced liver autophagy in the maintenance of lipid metabolism during sepsis.
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9
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10
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